Subunit of phosphatidylinositol (PtdIns) 3-kinase complexes I and II; Complex I is essential in autophagy, Complex II is required for vacuolar protein sorting; required for overflow degradation of misfolded proteins when ERAD is saturated; C-terminus has novel globular fold essential for autophagy through the targeting of the PI3-kinase complex I to the pre-autophagosomal structure; ortholog of higher eukaryote gene Beclin 1; human BECN1 can complement yeast null mutant [Source:SGD;Acc:S000006041]
APG6, ATG6, VPT30
Chromosome XVI: 322,071-323,744 forward strand.
This transcript has 1 exon, is annotated with 17 domains and features, is associated with 48 variant alleles and maps to 29 oligo probes.
This transcript is a product of gene YPL120W Show transcript tableHide transcript table
Transcript ID | Name | bp | Protein | Translation ID | Biotype | UniProt Match | Flags |
---|---|---|---|---|---|---|---|
YPL120W_mRNA | VPS30 | 1674 | 557aa | YPL120W | Protein coding | Q02948 | Ensembl Canonical, |