Alpha-1,2-specific exomannosidase of the endoplasmic reticulum; involved in glycan trimming of both folded and misfolded glycoproteins; complexes with Pdi1p, and trims a mannose from Man8GlcNac2 glycans to generate Man7GlcNac2, an oligosaccharide signal on glycoproteins destined for ER-associated protein degradation; requires Pdi1p for stability and substrate recognition; human homolog EDEM1 can complement yeast null mutant [Source:SGD;Acc:S000001247]
HTM1
Chromosome VIII: 506,319-508,709 forward strand.
R64-1-1:BK006934.2
This gene has 1 transcript (splice variant), 204 orthologues and 1 paralogue.
Transcript ID | Name | bp | Protein | Translation ID | Biotype | UniProt Match | Flags |
---|---|---|---|---|---|---|---|
YHR204W_mRNA | MNL1 | 2391 | 796aa | YHR204W | Protein coding | P38888 | Ensembl Canonical, |