Description
DNA replication initiation factor; recruited to MCM pre-RC complexes at replication origins; promotes release of MCM from Mcm10p, recruits elongation machinery; binds tightly to ssDNA, which disrupts interaction with the MCM helicase and stalls it during replication stress; mutants in human homolog may cause velocardiofacial and DiGeorge syndromes [Source:SGD;Acc:S000004093]
Gene Synonyms
SLD4
Location
Chromosome XII: 343,989-345,941 reverse strand.
R64-1-1:BK006945.2
About this gene
This gene has 1 transcript (splice variant) and 204 orthologues.
Transcripts
