DNA replication initiation factor; recruited to MCM pre-RC complexes at replication origins; promotes release of MCM from Mcm10p, recruits elongation machinery; binds tightly to ssDNA, which disrupts interaction with the MCM helicase and stalls it during replication stress; mutants in human homolog may cause velocardiofacial and DiGeorge syndromes [Source:SGD;Acc:S000004093]

SLD4

Chromosome XII: 343,989-345,941 reverse strand.

R64-1-1:BK006945.2

This gene has 1 transcript (splice variant) and 204 orthologues.

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