Description
5-phospho-ribosyl-1(alpha)-pyrophosphate synthetase; synthesizes PRPP, which is required for nucleotide, histidine, and tryptophan biosynthesis; plays a key role in cell wall integrity (CWI) pathway; one of five related enzymes, which are active as heteromultimeric complexes; missense mutations in human homolog PRPS1 are associated with neuropathic Arts syndrome and Charcot-Marie Tooth (CMTX5) disease [Source:SGD;Acc:S000001664]
Gene Synonyms
PRP1
Location
Chromosome XI: 107,316-108,599 forward strand.
R64-1-1:BK006944.2
About this gene
This gene has 1 transcript (splice variant), 7 orthologues and 4 paralogues.
Transcripts
