Description
Single-stranded DNA origin-binding and annealing protein; required for initiation of DNA replication; phosphorylated in S phase by cyclin-dependent kinases (Cdks), promoting origin binding, DNA replication and Dpb11p complex formation; component of the preloading complex; binds the Mcm2-7p complex to prevent inappropriate Mcm2-7p interaction with the GINS complex in G1; required for S phase checkpoint; relative distribution to the nucleus increases upon DNA replication stress [Source:SGD;Acc:S000001591]
Gene Synonyms
DRC1
Location
Chromosome XI: 234,426-235,787 forward strand.
R64-1-1:BK006944.2
About this gene
This gene has 1 transcript (splice variant).
Transcripts
