Description
Essential ATP-binding protein required for DNA replication; component of the pre-replicative complex (pre-RC) which requires ORC to associate with chromatin and is in turn required for Mcm2-7p DNA association; homologous to S. pombe Cdc18p; relocalizes from nucleus to cytoplasm upon DNA replication stress; degraded in response to plasma membrane stress [Source:SGD;Acc:S000003730]
Location
Chromosome X: 69,338-70,879 forward strand.
R64-1-1:BK006943.2
About this gene
This gene has 1 transcript (splice variant), 208 orthologues and 2 paralogues.
Transcripts
