Description
Endosomal subunit of membrane-associated retromer complex; required for retrograde transport; receptor that recognizes retrieval signals on cargo proteins, forms subcomplex with Vps26p and Vps29p that selects cargo proteins for retrieval; interacts with Ypt7p; overexpression of wild-type human VPS35 or Parkinson's-associated vps35-D686N or vps35-P299S variants complements Ni2+ resistance and Cd2+ sensitivity of yeast vps35 null mutant [Source:SGD;Acc:S000003690]
Gene Synonyms
GRD9, VPT7
Location
Chromosome X: 131,101-133,935 reverse strand.
R64-1-1:BK006943.2
About this gene
This gene has 1 transcript (splice variant) and 220 orthologues.
Transcripts
