Description
Negative regulator of actin nucleation-promoting factor activity; interacts with Las17p, a homolog of human Wiskott-Aldrich Syndrome protein (WASP), via an N-terminal SH3 domain, and along with PIN3 cooperatively inhibits the nucleation of actin filaments; overexpression blocks receptor-mediated endocytosis; protein increases in abundance and forms nuclear foci in response to DNA replication stress; LSB1 has a paralog, PIN3, that arose from the whole genome duplication [Source:SGD;Acc:S000003368]
Location
Chromosome VII: 762,428-763,153 forward strand.
R64-1-1:BK006941.2
About this gene
This gene has 1 transcript (splice variant), 206 orthologues and 5 paralogues.
Transcripts
