Description
Endosomal protein involved in turnover of plasma membrane proteins; member of the DUP380 subfamily of conserved, often subtelomeric COS genes; required for the multivesicular vesicle body sorting pathway that internalizes plasma membrane proteins for degradation; Cos proteins provide ubiquitin in trans for nonubiquitinated cargo proteins [Source:SGD;Acc:S000003232]
Location
Chromosome VII: 2,790-3,932 forward strand.
R64-1-1:BK006941.2
About this gene
This gene has 1 transcript (splice variant) and 13 paralogues.
Transcripts
| Transcript ID | Name | bp | Protein | Translation ID | Biotype | UniProt Match | Flags |
|---|---|---|---|---|---|---|---|
| YGL263W_mRNA | COS12 | 1143 | 380aa | YGL263W | Protein coding | P53053 | Ensembl Canonical, |
