Description
Glutathione-dependent oxidoreductase; hydroperoxide and superoxide-radical responsive; monothiol glutaredoxin subfamily member along with Grx3p and Grx5p; protects cells from oxidative damage; with Grx3p, binds to Aft1p in iron-replete conditions, promoting its dissociation from promoters; mutant has increased aneuploidy tolerance; transcription regulated by Yap5p; GRX4 has a paralog, GRX3, that arose from the whole genome duplication [Source:SGD;Acc:S000000976]
Location
Chromosome V: 538,434-539,168 reverse strand.
R64-1-1:BK006939.2
About this gene
This gene has 1 transcript (splice variant), 224 orthologues and 2 paralogues.
Transcripts
