Description
Major isoform of large subunit of ribonucleotide-diphosphate reductase; the RNR complex catalyzes rate-limiting step in dNTP synthesis, regulated by DNA replication and DNA damage checkpoint pathways via localization of small subunits; relative distribution to the nucleus increases upon DNA replication stress; RNR1 has a paralog, RNR3, that arose from the whole genome duplication [Source:SGD;Acc:S000000872]
Gene Synonyms
CRT7, RIR1, SDS12
Location
Chromosome V: 298,950-301,616 forward strand.
R64-1-1:BK006939.2
About this gene
This gene has 1 transcript (splice variant), 264 orthologues and 1 paralogue.
Transcripts
