Description
Conserved NAD+ dependent histone deacetylase of the Sirtuin family; deacetylation targets are primarily nuclear proteins; required for telomere hypercluster formation in quiescent yeast cells; involved in regulation of lifespan; plays roles in silencing at HML, HMR, telomeres, and rDNA; negatively regulates initiation of DNA replication; functions as regulator of autophagy like mammalian homolog SIRT1, and also of mitophagy [Source:SGD;Acc:S000002200]
Gene Synonyms
MAR1
Location
Chromosome IV: 376,757-378,445 reverse strand.
R64-1-1:BK006938.2
About this gene
This gene has 1 transcript (splice variant), 156 orthologues and 2 paralogues.
Transcripts
