Description
DNA N-glycosylase and apurinic/apyrimidinic (AP) lyase; involved in base excision repair; acts in both nucleus and mitochondrion; creates a double-strand break at mtDNA origins that stimulates replication in response to oxidative stress; required for maintaining mitochondrial genome integrity; NTG1 has a paralog, NTG2, that arose from the whole genome duplication [Source:SGD;Acc:S000000013]
Gene Synonyms
FUN33, SCR1, ogg2
Location
Chromosome I: 126,903-128,102 reverse strand.
R64-1-1:BK006935.2
About this gene
This gene has 1 transcript (splice variant), 1 orthologue and 1 paralogue.
Transcripts
