Summary
- Splice variants
- Transcript comparison
- Gene alleles
Sequence
- Secondary Structure
Comparative Genomics
Ontologies
- GO: Anatomical entity
Phenotypes
Genetic Variation
- Variant table
- Variant image
- Structural variants
Gene expression
Pathway
Molecular interactions
External references
Supporting evidence
ID History
- Gene history

Configure this page

Share this page

Bookmark this page

.

Gene: Top1mt ENSRNOG00000007500

.

Description

DNA topoisomerase I mitochondrial [Source:RGD Symbol;Acc:1303177]

Location

Primary_assembly 7: 109,139,527-109,246,799 reverse strand.

GRCr8:CM070397.1

About this gene

This gene has 7 transcripts (splice variants), 77 orthologues, 1 paralogue and is associated with 5 phenotypes.

Transcripts

Show transcript tableHide transcript table

Transcript ID	Name	bp	Protein	Translation ID	Biotype	UniProt Match	Flags
ENSRNOT00000009965.6	Top1mt-201	2000	641aa	ENSRNOP00000009965.4	Gene/transcipt that contains an open reading frame (ORF).Protein coding	Q6IM78	A single transcript chosen for a gene which is the most conserved, most highly expressed, has the longest coding sequence and is represented in other key resources, such as NCBI and UniProt. This is defined in detail on http://www.ensembl.org/info/genome/genebuild/canonical.htmlEnsembl Canonical, APPRIS P2: Where the APPRIS core modules are unable to choose a clear principal variant (approximately 25% of human protein coding genes), the database chooses two or more of the CDS variants as "candidates" to be the principal variant. APPRIS is a system to annotate alternatively spliced transcripts based on a range of computational methods to identify the most functionally important transcript(s) of a gene. APPRIS P2,
ENSRNOT00000166649.1	Top1mt-207	2867	610aa	ENSRNOP00000100549.1	Gene/transcipt that contains an open reading frame (ORF).Protein coding	-	-
ENSRNOT00000155631.1	Top1mt-206	2810	591aa	ENSRNOP00000105400.1	Gene/transcipt that contains an open reading frame (ORF).Protein coding	-	-
ENSRNOT00000106595.2	Top1mt-205	2714	559aa	ENSRNOP00000090208.2	Gene/transcipt that contains an open reading frame (ORF).Protein coding	A0A8I6ADZ0	-
ENSRNOT00000088064.3	Top1mt-204	2234	568aa	ENSRNOP00000070025.2	Gene/transcipt that contains an open reading frame (ORF).Protein coding	A0A0G2JWV0	APPRIS ALT2: For genes in which the APPRIS core modules are unable to choose a clear principal isoform, the ALT1 is the candidate transcript(s) models that appear to be conserved in fewer than three tested species. APPRIS is a system to annotate alternatively spliced transcripts based on a range of computational methods to identify the most functionally important transcript(s) of a gene. APPRIS ALT2,
ENSRNOT00000056554.6	Top1mt-202	1528	321aa	ENSRNOP00000053394.4	Gene/transcipt that contains an open reading frame (ORF).Protein coding	F1LNW6	-
ENSRNOT00000076014.4	Top1mt-203	1408	281aa	ENSRNOP00000068013.3	Gene/transcipt that contains an open reading frame (ORF).Protein coding	A0A096MJ69	-

.

Summary

.

.