Gene: TNF ENSG00000232810

Description

tumor necrosis factor [Source:HGNC Symbol;Acc:HGNC:11892]

Gene Synonyms

DIF, TNF-ALPHA, TNFA, TNFSF2

Location

Chromosome 6: 31,575,565-31,578,336 forward strand.

GRCh38:CM000668.2

View alleles of this gene on alternative sequences

About this gene

This gene has 2 transcripts (splice variants), 1 gene allele, 247 orthologues, 8 paralogues and is associated with 3 phenotypes.

Transcripts

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Transcript ID	Name	bp	Protein	Translation ID	Biotype	CCDS	UniProt Match	RefSeq Match	Flags
ENST00000449264.3	TNF-208	1678	233aa	ENSP00000398698.2	Gene/transcipt that contains an open reading frame (ORF).Protein coding	CCDS4702	P01375 Q5STB3	NM_000594.4	The Matched Annotation from NCBI and EMBL-EBI is a collaboration between Ensembl/GENCODE and RefSeq. The MANE Select is a default transcript per human gene that is representative of biology, well-supported, expressed and highly-conserved. This transcript set matches GRCh38 and is 100% identical between RefSeq and Ensembl/GENCODE for 5' UTR, CDS, splicing and 3'UTR.MANE Select, A single transcript chosen for a gene which is the most conserved, most highly expressed, has the longest coding sequence and is represented in other key resources, such as NCBI and UniProt. This is defined in detail on http://www.ensembl.org/info/genome/genebuild/canonical.htmlEnsembl Canonical, GENCODE Primary represents a minimal set that contains MANE Select, MANE Plus Clinical and Ensembl Canonical transcripts and transcripts containing any conserved exons and common alternative splicing events (including exons skips) that are absent from the MANE and Ensembl Canonical transcripts for protein-coding genes. Other biotypes will have the GENCODE Primary flag added to the Ensembl Canonical transcript and for lncRNA genes only this will be the transcripts with the longest genomic span.GENCODE Primary, A subset of the GENCODE transcript set, containing only 5' and 3' complete transcripts at protein-coding genes.GENCODE Basic, APPRIS P1: Transcript(s) expected to code for the main functional isoform based solely on the core modules in the APPRIS. APPRIS is a system to annotate alternatively spliced transcripts based on a range of computational methods to identify the most functionally important transcript(s) of a gene. APPRIS P1, TSL 1: A transcript where all splice junctions are supported by at least one non-suspect mRNA. The Transcript Support Level (TSL) is a method to highlight the well-supported and poorly-supported transcript models for users, based on the type and quality of the alignments used to annotate the transcript. TSL:1,
ENST00000699334.1	TNF-209	656	73aa	ENSP00000514308.1	Gene/transcipt that contains an open reading frame (ORF).Protein coding		A0A8V8TNL2	-	A subset of the GENCODE transcript set, containing only 5' and 3' complete transcripts at protein-coding genes.GENCODE Basic,

Gene: TNF ENSG00000232810

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Gene: TNF ENSG00000232810

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