Upcoming Ensembl Platform Transition

This is the final release of its kind on this website.

In summer 2026, this site will bring you to the new Ensembl platform currently at beta.ensembl.org.
Please bookmark this archive to retain access to the current site, tools and functionality until they are available on the new platform -> jun2026.archive.ensembl.org

Human (GRCh38.p14)
Description

mutL homolog 1 [Source:HGNC Symbol;Acc:HGNC:7127]

Gene Synonyms

COCA2, FCC2, HNPCC, HNPCC2, MLH-1

Location

Chromosome 3: 36,992,834-37,051,505 forward strand.

GRCh38:CM000665.2

About this gene

This gene has 74 transcripts (splice variants), 204 orthologues, 3 paralogues and is associated with 130 phenotypes.

Transcript IDNamebpProteinTranslation IDBiotypeCCDSUniProt MatchRefSeq MatchFlags
ENST00000231790.8MLH1-2012494756aaENSP00000231790.3
 
Protein coding
CCDS2663P40692-1 NM_000249.4MANE SelectEnsembl CanonicalGENCODE PrimaryGENCODE BasicAPPRIS P1TSL:1
ENST00001144777.1MLH1-2742836756aaENSP00000802046.1
 
Protein coding
CCDS2663--Ensembl Canonical ExtendedGENCODE BasicAPPRIS P1
ENST00001113531.1MLH1-2713494521aaENSP00000783336.1
 
Protein coding
--GENCODE PrimaryGENCODE Basic
ENST00000931189.2MLH1-2402857763aaENSP00000601248.1
 
Protein coding
--GENCODE PrimaryGENCODE Basic
ENST00000948704.2MLH1-2432833755aaENSP00000618763.1
 
Protein coding
--GENCODE Basic
ENST00001124847.1MLH1-2722782701aaENSP00000794652.1
 
Protein coding
--GENCODE Basic
ENST00000616768.7MLH1-2232743725aaENSP00000480669.3
 
Protein coding
A0A087WX20 -GENCODE PrimaryGENCODE BasicTSL:2
ENST00000713802.2MLH1-2392737723aaENSP00000519108.1
 
Protein coding
A0AAQ5BGZ2 -GENCODE Basic
ENST00001047810.1MLH1-2652737723aaENSP00000717627.1
 
Protein coding
--GENCODE Basic
ENST00000673673.3MLH1-2242671701aaENSP00000500979.2
 
Protein coding
A0A669KAW3 -GENCODE Basic
ENST00000458205.7MLH1-2162658515aaENSP00000402667.2
 
Protein coding
CCDS54563P40692-2 -GENCODE BasicTSL:1
ENST00000674019.2MLH1-2352649515aaENSP00000501081.1
 
Protein coding
CCDS54563P40692-2 -GENCODE Basic
ENST00000456676.8MLH1-2132629687aaENSP00000416687.3
 
Protein coding
H0Y818 -GENCODE BasicTSL:1
ENST00000976356.1MLH1-2492629687aaENSP00000646173.1
 
Protein coding
--GENCODE PrimaryGENCODE Basic
ENST00000536378.6MLH1-2212621515aaENSP00000444286.2
 
Protein coding
CCDS54563P40692-2 -GENCODE BasicTSL:2
ENST00000492474.6MLH1-2202572515aaENSP00000518393.1
 
Protein coding
CCDS54563P40692-2 -GENCODE BasicTSL:5
ENST00000485889.3MLH1-2192569515aaENSP00000518946.1
 
Protein coding
CCDS54563P40692-2 -GENCODE BasicTSL:5
ENST00000466900.7MLH1-2172547515aaENSP00000519069.1
 
Protein coding
CCDS54563P40692-2 -GENCODE BasicTSL:4
ENST00000429117.7MLH1-2042532658aaENSP00000407019.2
 
Protein coding
CCDS54562P40692-3 -TSL:4
ENST00000455445.7MLH1-2122486515aaENSP00000398272.2
 
Protein coding
CCDS54563P40692-2 -GENCODE BasicTSL:2
ENST00000435176.6MLH1-2062480658aaENSP00000402564.1
 
Protein coding
CCDS54562P40692-3 -GENCODE BasicTSL:2
ENST00000931190.2MLH1-2412464632aaENSP00000601249.1
 
Protein coding
--GENCODE Basic
ENST00000948705.2MLH1-2442464632aaENSP00000618764.1
 
Protein coding
--GENCODE Basic
ENST00000673990.3MLH1-2342405415aaENSP00000518979.1
 
Protein coding
A0AAQ5BGN3 -GENCODE Basic
ENST00000413740.3MLH1-2032400611aaENSP00000416476.2
 
Protein coding
H0Y806 -GENCODE BasicTSL:1
ENST00000539477.7MLH1-2222393515aaENSP00000443665.1
 
Protein coding
CCDS54563P40692-2 -GENCODE BasicTSL:2
ENST00000931191.2MLH1-2422311581aaENSP00000601250.1
 
Protein coding
--GENCODE Basic
ENST00000450420.7MLH1-2102291520aaENSP00000393006.2
 
Protein coding
H0Y4N0 -GENCODE BasicTSL:1
ENST00000673715.2MLH1-2272275633aaENSP00000501301.1
 
Protein coding
A0A669KBK2 -GENCODE Basic
ENST00000673899.2MLH1-2312104512aaENSP00000501030.1
 
Protein coding
A0A669KB03 -GENCODE Basic
ENST00001124848.1MLH1-2732101525aaENSP00000794653.1
 
Protein coding
--GENCODE Basic
ENST00000441265.6MLH1-2071982327aaENSP00000398392.2
 
Protein coding
E7EUC9 -GENCODE BasicTSL:5
ENST00001107437.1MLH1-2701806484aaENSP00000777242.1
 
Protein coding
--GENCODE Basic
ENST00001047794.1MLH1-252340248aaENSP00000717611.1
 
Nonsense mediated decay
---
ENST00000976352.1MLH1-245330748aaENSP00000646169.1
 
Nonsense mediated decay
---
ENST00001047795.1MLH1-2533097138aaENSP00000717612.1
 
Nonsense mediated decay
---
ENST00000673947.1MLH1-232269838aaENSP00000501304.1
 
Nonsense mediated decay
F2Z298 --
ENST00001047801.1MLH1-258264638aaENSP00000717618.1
 
Nonsense mediated decay
---
ENST00001047802.1MLH1-259264338aaENSP00000717619.1
 
Nonsense mediated decay
---
ENST00001047807.1MLH1-263262238aaENSP00000717624.1
 
Nonsense mediated decay
---
ENST00001047797.1MLH1-2542619358aaENSP00000717614.1
 
Nonsense mediated decay
---
ENST00000976357.1MLH1-250258738aaENSP00000646174.1
 
Nonsense mediated decay
---
ENST00001078880.1MLH1-2672527636aaENSP00000748686.1
 
Nonsense mediated decay
---
ENST00001047800.1MLH1-2572520232aaENSP00000717617.1
 
Nonsense mediated decay
---
ENST00001078881.1MLH1-2682520118aaENSP00000748687.1
 
Nonsense mediated decay
---
ENST00001047804.1MLH1-2602516199aaENSP00000717621.1
 
Nonsense mediated decay
---
ENST00001047805.1MLH1-2612515303aaENSP00000717622.1
 
Nonsense mediated decay
---
ENST00000673972.1MLH1-233247338aaENSP00000501281.1
 
Nonsense mediated decay
F2Z298 --
ENST00000454028.6MLH1-211246838aaENSP00000392649.1
 
Nonsense mediated decay
F2Z298 -TSL:5
ENST00000432299.6MLH1-205244448aaENSP00000416783.1
 
Nonsense mediated decay
E9PF25 -TSL:1
ENST00001047798.1MLH1-2552434159aaENSP00000717615.1
 
Nonsense mediated decay
---
ENST00000976354.1MLH1-2472431264aaENSP00000646171.1
 
Nonsense mediated decay
---
ENST00001047806.1MLH1-262242938aaENSP00000717623.1
 
Nonsense mediated decay
---
ENST00000976353.1MLH1-246242638aaENSP00000646170.1
 
Nonsense mediated decay
---
ENST00000674111.1MLH1-2372403568aaENSP00000501162.1
 
Nonsense mediated decay
A0A669KBB4 --
ENST00001047811.1MLH1-2662353267aaENSP00000717628.1
 
Nonsense mediated decay
---
ENST00000458009.7MLH1-2152340314aaENSP00000411066.2
 
Nonsense mediated decay
H0Y793 -TSL:1
ENST00000673897.1MLH1-230233838aaENSP00000501109.1
 
Nonsense mediated decay
F2Z298 --
ENST00001047808.1MLH1-2642302525aaENSP00000717625.1
 
Nonsense mediated decay
---
ENST00000976355.1MLH1-2482275277aaENSP00000646172.1
 
Nonsense mediated decay
---
ENST00000447829.6MLH1-2092247143aaENSP00000399329.2
 
Nonsense mediated decay
H0Y5L7 -TSL:1
ENST00001078883.1MLH1-269224738aaENSP00000748689.1
 
Nonsense mediated decay
---
ENST00000413212.2MLH1-202218336aaENSP00000400844.2
 
Nonsense mediated decay
H0Y5U4 -TSL:5
ENST00001047799.1MLH1-2562162245aaENSP00000717616.1
 
Nonsense mediated decay
---
ENST00000976358.1MLH1-251201038aaENSP00000646175.1
 
Nonsense mediated decay
---
ENST00000457004.5MLH1-21466838aaENSP00000407773.1
 
Nonsense mediated decay
F2Z298 -TSL:3
ENST00000674107.1MLH1-2362827No protein-
 
Retained intron
---
ENST00000673889.1MLH1-2291799No protein-
 
Retained intron
---
ENST00000673713.1MLH1-2261586No protein-
 
Retained intron
---
ENST00000673741.1MLH1-2281495No protein-
 
Retained intron
---
ENST00000442249.6MLH1-2081303No protein-
 
Retained intron
--TSL:4
ENST00000476172.6MLH1-2181246No protein-
 
Retained intron
--TSL:3
ENST00000674125.1MLH1-2381167No protein-
 
Retained intron
---
ENST00000673686.1MLH1-2251127No protein-
 
Retained intron
---