Upcoming Ensembl Platform Transition

This is the final release of its kind on this website.

In summer 2026, this site will bring you to the new Ensembl platform currently at beta.ensembl.org.
Please bookmark this archive to retain access to the current site, tools and functionality until they are available on the new platform -> jun2026.archive.ensembl.org

Human (GRCh38.p14)
Description

tyrosine kinase with immunoglobulin like and EGF like domains 1 [Source:HGNC Symbol;Acc:HGNC:11809]

Gene Synonyms

JTK14, TIE

Location

Chromosome 1: 43,300,958-43,325,215 forward strand.

GRCh38:CM000663.2

About this gene

This gene has 21 transcripts (splice variants), 205 orthologues, 53 paralogues and is associated with 2 phenotypes.

Transcript IDNamebpProteinTranslation IDBiotypeCCDSUniProt MatchRefSeq MatchFlags
ENST00000372476.8TIE1-20138931138aaENSP00000361554.3
 
Protein coding
CCDS482P35590-1 NM_005424.5MANE SelectEnsembl CanonicalGENCODE PrimaryGENCODE BasicAPPRIS P1TSL:1
ENST00001143968.1TIE1-22139131138aaENSP00000810044.1
 
Protein coding
CCDS482--Ensembl Canonical ExtendedGENCODE BasicAPPRIS P1
ENST00001117197.1TIE1-22048301129aaENSP00000787002.1
 
Protein coding
--GENCODE Basic
ENST00000964802.2TIE1-21236131039aaENSP00000634861.1
 
Protein coding
--GENCODE Basic
ENST00001105660.1TIE1-2193438830aaENSP00000775465.1
 
Protein coding
--GENCODE Basic
ENST00000964803.2TIE1-2133351952aaENSP00000634862.1
 
Protein coding
--GENCODE Basic
ENST00001049430.1TIE1-2163980830aaENSP00000719247.1
 
Nonsense mediated decay
---
ENST00001049428.1TIE1-2143920991aaENSP00000719245.1
 
Nonsense mediated decay
---
ENST00001049429.1TIE1-2153747767aaENSP00000719246.1
 
Nonsense mediated decay
---
ENST00001049432.1TIE1-2183727360aaENSP00000719249.1
 
Nonsense mediated decay
---
ENST00000714825.1TIE1-2113645111aaENSP00000520026.1
 
Nonsense mediated decay
A0AAQ5BI97 --
ENST00001049431.1TIE1-2173608317aaENSP00000719248.1
 
Nonsense mediated decay
---
ENST00000473014.1TIE1-2043087No protein-
 
Protein coding CDS not defined
--TSL:2
ENST00000538015.2TIE1-2101140No protein-
 
Protein coding CDS not defined
--TSL:1
ENST00000461061.1TIE1-202656No protein-
 
Protein coding CDS not defined
--TSL:3
ENST00000488437.1TIE1-207651No protein-
 
Protein coding CDS not defined
--TSL:3
ENST00000471187.1TIE1-203625No protein-
 
Protein coding CDS not defined
--TSL:2
ENST00000492874.1TIE1-209617No protein-
 
Protein coding CDS not defined
--TSL:3
ENST00000485125.1TIE1-206557No protein-
 
Protein coding CDS not defined
--TSL:3
ENST00000492599.1TIE1-208391No protein-
 
Protein coding CDS not defined
--TSL:2
ENST00000480269.1TIE1-205333No protein-
 
Protein coding CDS not defined
--TSL:2