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Human (GRCh38.p14)
Description

mitogen-activated protein kinase kinase 4 [Source:HGNC Symbol;Acc:HGNC:6844]

Gene Synonyms

JNKK, JNKK1, MAPKK4, MEK4, MKK4, PRKMK4, SAPKK1, SEK1, SERK1, SKK1

Location

Chromosome 17: 12,020,808-12,143,830 forward strand.

GRCh38:CM000679.2

About this gene

This gene has 39 transcripts (splice variants), 276 orthologues, 8 paralogues and is associated with 87 phenotypes.

Transcript IDNamebpProteinTranslation IDBiotypeCCDSUniProt MatchRefSeq MatchFlags
ENST00000353533.10MAP2K4-2013778399aaENSP00000262445.5
 
Protein coding
CCDS11162P45985-1 NM_003010.4MANE SelectEnsembl CanonicalGENCODE PrimaryGENCODE BasicAPPRIS P4TSL:1
ENST00001142040.1MAP2K4-2393839399aaENSP00000803323.1
 
Protein coding
CCDS11162--Ensembl Canonical ExtendedGENCODE BasicAPPRIS P4
ENST00000415385.8MAP2K4-2023872410aaENSP00000410402.3
 
Protein coding
CCDS62095P45985-2 -GENCODE BasicAPPRIS ALT2TSL:2
ENST00000905332.2MAP2K4-2183785381aaENSP00000575391.1
 
Protein coding
--GENCODE BasicAPPRIS ALT2
ENST00000937444.2MAP2K4-2223761373aaENSP00000607503.1
 
Protein coding
--GENCODE Basic
ENST00000905333.2MAP2K4-2193719359aaENSP00000575392.1
 
Protein coding
--GENCODE Basic
ENST00000905334.2MAP2K4-2203719359aaENSP00000575393.1
 
Protein coding
--GENCODE Basic
ENST00000905331.2MAP2K4-2173599319aaENSP00000575390.1
 
Protein coding
--GENCODE Basic
ENST00001015186.1MAP2K4-2273591301aaENSP00000685003.1
 
Protein coding
--GENCODE Basic
ENST00000905330.2MAP2K4-2163539299aaENSP00000575389.1
 
Protein coding
--GENCODE Basic
ENST00000937443.2MAP2K4-2213269209aaENSP00000607502.1
 
Protein coding
--GENCODE Basic
ENST00001109658.1MAP2K4-2362254144aaENSP00000779463.1
 
Protein coding
--GENCODE Basic
ENST00001109657.1MAP2K4-2352081311aaENSP00000779462.1
 
Protein coding
--GENCODE PrimaryGENCODE Basic
ENST00001109659.1MAP2K4-2371845155aaENSP00000779464.1
 
Protein coding
--GENCODE PrimaryGENCODE Basic
ENST00001123927.1MAP2K4-2381592349aaENSP00000793732.1
 
Protein coding
--GENCODE Basic
ENST00001068339.1MAP2K4-2283958308aaENSP00000738145.1
 
Nonsense mediated decay
---
ENST00001068340.1MAP2K4-229384741aaENSP00000738146.1
 
Nonsense mediated decay
---
ENST00001015184.1MAP2K4-2263838308aaENSP00000685001.1
 
Nonsense mediated decay
---
ENST00001015183.1MAP2K4-225383380aaENSP00000685000.1
 
Nonsense mediated decay
---
ENST00000991255.1MAP2K4-2243828349aaENSP00000661072.1
 
Nonsense mediated decay
---
ENST00001068341.1MAP2K4-230381241aaENSP00000738147.1
 
Nonsense mediated decay
---
ENST00001068342.1MAP2K4-231374441aaENSP00000738148.1
 
Nonsense mediated decay
---
ENST00001068343.1MAP2K4-232367092aaENSP00000738149.1
 
Nonsense mediated decay
---
ENST00000991254.1MAP2K4-223339645aaENSP00000661071.1
 
Nonsense mediated decay
---
ENST00001068344.1MAP2K4-233332939aaENSP00000738150.1
 
Nonsense mediated decay
---
ENST00001068345.1MAP2K4-234320770aaENSP00000738151.1
 
Nonsense mediated decay
---
ENST00000602811.5MAP2K4-215113641aaENSP00000473582.1
 
Nonsense mediated decay
R4GN68 -TSL:5
ENST00000602375.5MAP2K4-212106492aaENSP00000473472.1
 
Nonsense mediated decay
R4GN37 -TSL:5
ENST00000602686.5MAP2K4-21497741aaENSP00000473458.1
 
Nonsense mediated decay
R4GN68 -TSL:5
ENST00000602305.5MAP2K4-21196145aaENSP00000473606.1
 
Nonsense mediated decay
J3QLE2 -TSL:5
ENST00000602537.5MAP2K4-21394841aaENSP00000473511.1
 
Nonsense mediated decay
R4GN68 -TSL:5
ENST00000538465.7MAP2K4-20492516aaENSP00000467239.1
 
Nonsense mediated decay
K7EP58 -TSL:5CDS 5' incomplete
ENST00000582183.5MAP2K4-20755145aaENSP00000463507.1
 
Nonsense mediated decay
J3QLE2 -TSL:4
ENST00000581941.5MAP2K4-206813No protein-
 
Protein coding CDS not defined
--TSL:3
ENST00000579089.5MAP2K4-205571No protein-
 
Protein coding CDS not defined
--TSL:4
ENST00000582897.5MAP2K4-209482No protein-
 
Protein coding CDS not defined
--TSL:5
ENST00000536413.2MAP2K4-2033852No protein-
 
Retained intron
--TSL:2
ENST00000582377.1MAP2K4-208648No protein-
 
Retained intron
--TSL:3
ENST00000585076.1MAP2K4-210543No protein-
 
Retained intron
--TSL:4