RecQ family nucleolar DNA helicase; role in genome integrity maintenance, chromosome synapsis, meiotic joint molecule/crossover formation; stimulates activity of Top3p; rapidly lost in response to rapamycin in Rrd1p-dependent manner; forms nuclear foci upon DNA replication stress; yeast SGS1 complements mutations in human homolog BLM implicated in Bloom syndrome; also similar to human WRN implicated in Werner syndrome; human BLM and WRN can each complement yeast null mutant [Source:SGD;Acc:S000004802]
Chromosome XIII: 640,915-645,258 reverse strand.
This transcript has 1 exon, is annotated with 47 domains and features, is associated with 88 variant alleles and maps to 29 oligo probes.
This transcript is a product of gene YMR190C Show transcript tableHide transcript table
Transcript ID | Name | bp | Protein | Translation ID | Biotype | UniProt Match | Flags |
---|---|---|---|---|---|---|---|
YMR190C_mRNA | SGS1 | 4344 | 1447aa | YMR190C | Protein coding | P35187 | Ensembl Canonical, |