Description
RecQ family nucleolar DNA helicase; role in genome integrity maintenance, chromosome synapsis, meiotic joint molecule/crossover formation; stimulates activity of Top3p; rapidly lost in response to rapamycin in Rrd1p-dependent manner; forms nuclear foci upon DNA replication stress; yeast SGS1 complements mutations in human homolog BLM implicated in Bloom syndrome; also similar to human WRN implicated in Werner syndrome; human BLM and WRN can each complement yeast null mutant [Source:SGD;Acc:S000004802]
Location
Chromosome XIII: 640,915-645,258 reverse strand.
R64-1-1:BK006946.2
About this gene
This gene has 1 transcript (splice variant) and 211 orthologues.
Transcripts
| Transcript ID | Name | bp | Protein | Translation ID | Biotype | UniProt Match | Flags |
|---|---|---|---|---|---|---|---|
| YMR190C_mRNA | SGS1 | 4344 | 1447aa | YMR190C | Protein coding | P35187 | Ensembl Canonical, |
