Description
ATP-dependent RNA helicase of the SFI superfamily; involved in nonsense mediated mRNA decay; required for efficient translation termination at nonsense codons and targeting of NMD substrates to P-bodies; binds to the small ribosomal subunit via an interaction with Rps26; forms cytoplasmic foci upon DNA replication stress [Source:SGD;Acc:S000004685]
Gene Synonyms
IFS2, MOF4, SUP113, UPF1
Location
Chromosome XIII: 426,712-429,627 reverse strand.
R64-1-1:BK006946.2
About this gene
This gene has 1 transcript (splice variant), 252 orthologues and 3 paralogues.
Transcripts
