Description
Serine-threonine kinase and endoribonuclease; transmembrane protein that mediates the unfolded protein response (UPR) by regulating Hac1p synthesis through HAC1 mRNA splicing; role in homeostatic adaptation to ER stress; Kar2p binds inactive Ire1p and releases from it upon ER stress [Source:SGD;Acc:S000001121]
Gene Synonyms
ERN1
Location
Chromosome VIII: 258,244-261,591 reverse strand.
R64-1-1:BK006934.2
About this gene
This gene has 1 transcript (splice variant) and 134 orthologues.
Transcripts
| Transcript ID | Name | bp | Protein | Translation ID | Biotype | UniProt Match | Flags |
|---|---|---|---|---|---|---|---|
| YHR079C_mRNA | IRE1 | 3348 | 1115aa | YHR079C | Protein coding | P32361 | Ensembl Canonical, |
