Serine-threonine kinase and endoribonuclease; transmembrane protein that mediates the unfolded protein response (UPR) by regulating Hac1p synthesis through HAC1 mRNA splicing; role in homeostatic adaptation to ER stress; Kar2p binds inactive Ire1p and releases from it upon ER stress [Source:SGD;Acc:S000001121]

ERN1

Chromosome VIII: 258,244-261,591 reverse strand.

R64-1-1:BK006934.2

This gene has 1 transcript (splice variant) and 134 orthologues.

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