Description
DDK (Dbf4-dependent kinase) catalytic subunit; required for origin firing and replication fork progression in mitotic S phase through phosphorylation of Mcm2-7p complexes and Cdc45p; kinase activity correlates with cyclical DBF4 expression; required for pre-meiotic DNA replication, meiotic DSB formation, recruitment of monopolin complex to kinetochores during meiosis I, regulation of meiosis-specific Ndt80p; mutation complemented by human CDC7 and DBF4 co-expression [Source:SGD;Acc:S000002175]
Gene Synonyms
LSD6, SAS1
Location
Chromosome IV: 424,209-425,732 forward strand.
R64-1-1:BK006938.2
About this gene
This gene has 1 transcript (splice variant), 207 orthologues and 4 paralogues.
Transcripts
| Transcript ID | Name | bp | Protein | Translation ID | Biotype | UniProt Match | Flags |
|---|---|---|---|---|---|---|---|
| YDL017W_mRNA | CDC7 | 1524 | 507aa | YDL017W | Protein coding | P06243 | Ensembl Canonical, |
