Summary
- Splice variants
- Transcript comparison
- Gene alleles
Sequence
- Secondary Structure
Comparative Genomics
Ontologies
- GO: Anatomical entity
Phenotypes
Genetic Variation
- Variant table
- Variant image
- Structural variants
Gene expression
Pathway
Molecular interactions
Regulation
External references
Supporting evidence
ID History
- Gene history

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Gene: Sirt1 ENSRNOG00000051592

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Description

sirtuin 1 [Source:RGD Symbol;Acc:1308542]

Gene Synonyms

Sir2

Location

Primary_assembly 20: 25,305,476-25,328,000 forward strand.

GRCr8:CM070410.1

About this gene

This gene has 5 transcripts (splice variants), 155 orthologues, 6 paralogues and is associated with 67 phenotypes.

Transcripts

Show transcript tableHide transcript table

Transcript ID	Name	bp	Protein	Translation ID	Biotype	UniProt Match	Flags
ENSRNOT00000095567.2	Sirt1-202	3885	741aa	ENSRNOP00000086140.1	Gene/transcipt that contains an open reading frame (ORF).Protein coding	A0A8I6A306	A single transcript chosen for a gene which is the most conserved, most highly expressed, has the longest coding sequence and is represented in other key resources, such as NCBI and UniProt. This is defined in detail on http://www.ensembl.org/info/genome/genebuild/canonical.htmlEnsembl Canonical, APPRIS P2: Where the APPRIS core modules are unable to choose a clear principal variant (approximately 25% of human protein coding genes), the database chooses two or more of the CDS variants as "candidates" to be the principal variant. APPRIS is a system to annotate alternatively spliced transcripts based on a range of computational methods to identify the most functionally important transcript(s) of a gene. APPRIS P2,
ENSRNOT00000170626.1	Sirt1-205	3989	730aa	ENSRNOP00000111831.1	Gene/transcipt that contains an open reading frame (ORF).Protein coding	-	-
ENSRNOT00000111766.2	Sirt1-203	3950	702aa	ENSRNOP00000094805.1	Gene/transcipt that contains an open reading frame (ORF).Protein coding	A0A8I6AMW7	APPRIS ALT2: For genes in which the APPRIS core modules are unable to choose a clear principal isoform, the ALT1 is the candidate transcript(s) models that appear to be conserved in fewer than three tested species. APPRIS is a system to annotate alternatively spliced transcripts based on a range of computational methods to identify the most functionally important transcript(s) of a gene. APPRIS ALT2,
ENSRNOT00000119601.2	Sirt1-204	3164	444aa	ENSRNOP00000094468.1	Gene/transcipt that contains an open reading frame (ORF).Protein coding	A0A8I6B0Z5	-
ENSRNOT00000078739.3	Sirt1-201	1724	554aa	ENSRNOP00000070943.2	Gene/transcipt that contains an open reading frame (ORF).Protein coding	A0A182DWI7	-

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Strains

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Genomic alignments

Gene tree

Orthologues

Paralogues

Families (Not available)

More views of comparative genomics data, such as multiple alignments and synteny, are available on the Location page for this gene.

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Personal Data