Summary
- Splice variants
- Transcript comparison
- Gene alleles
Sequence
- Secondary Structure
Comparative Genomics
- Genomic alignments
- Gene tree
- Gene gain/loss tree
- Orthologues
- Paralogues
- Strains
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  - Orthologues
  - Paralogues
Ontologies
- GO: Anatomical entity
Phenotypes
Genetic Variation
Gene expression
Pathway
Molecular interactions
Regulation
External references
Supporting evidence
ID History
- Gene history

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Gene: Chek2 ENSMUSG00000029521

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Description

checkpoint kinase 2 [Source:MGI Symbol;Acc:MGI:1355321]

Gene Synonyms

CHK2, Rad53

Location

Chromosome 5: 110,987,845-111,022,011 forward strand.

GRCm39:CM000998.3

About this gene

This gene has 6 transcripts (splice variants), 203 orthologues and is associated with 9 phenotypes.

Transcripts

Show transcript tableHide transcript table

Transcript ID	Name	bp	Protein	Translation ID	Biotype	CCDS	UniProt Match	Flags
ENSMUST00000066160.3	Chek2-201	2276	546aa	ENSMUSP00000066679.2	Gene/transcipt that contains an open reading frame (ORF).Protein coding	CCDS19533	Q543W6 Q9Z265	A single transcript chosen for a gene which is the most conserved, most highly expressed, has the longest coding sequence and is represented in other key resources, such as NCBI and UniProt. This is defined in detail on http://www.ensembl.org/info/genome/genebuild/canonical.htmlEnsembl Canonical, GENCODE Primary represents a minimal set that contains MANE Select, MANE Plus Clinical and Ensembl Canonical transcripts and transcripts containing any conserved exons and common alternative splicing events (including exons skips) that are absent from the MANE and Ensembl Canonical transcripts for protein-coding genes. Other biotypes will have the GENCODE Primary flag added to the Ensembl Canonical transcript and for lncRNA genes only this will be the transcripts with the longest genomic span.GENCODE Primary, A subset of the GENCODE transcript set, containing only 5' and 3' complete transcripts at protein-coding genes.GENCODE Basic, APPRIS P1: Transcript(s) expected to code for the main functional isoform based solely on the core modules in the APPRIS. APPRIS is a system to annotate alternatively spliced transcripts based on a range of computational methods to identify the most functionally important transcript(s) of a gene. APPRIS P1, TSL 1: A transcript where all splice junctions are supported by at least one non-suspect mRNA. The Transcript Support Level (TSL) is a method to highlight the well-supported and poorly-supported transcript models for users, based on the type and quality of the alignments used to annotate the transcript. TSL:1,
ENSMUST00000198373.2	Chek2-203	446	42aa	ENSMUSP00000142506.2	Gene/transcipt that contains an open reading frame (ORF).Protein coding		A0A0G2JDU5	TSL 3: A transcript where the only support is from a single EST The Transcript Support Level (TSL) is a method to highlight the well-supported and poorly-supported transcript models for users, based on the type and quality of the alignments used to annotate the transcript. TSL:3, 3' truncation in transcript evidence prevents annotation of the end of the CDS.CDS 3' incomplete,
ENSMUST00000200172.2	Chek2-205	328	40aa	ENSMUSP00000142475.2	Gene/transcipt that contains an open reading frame (ORF).Protein coding		A0A0G2JDS0	TSL 2: A transcript where the best supporting mRNA is flagged as suspect or the support is from multiple ESTs The Transcript Support Level (TSL) is a method to highlight the well-supported and poorly-supported transcript models for users, based on the type and quality of the alignments used to annotate the transcript. TSL:2, 3' truncation in transcript evidence prevents annotation of the end of the CDS.CDS 3' incomplete,
ENSMUST00000199937.5	Chek2-204	2190	207aa	ENSMUSP00000143558.2	Nonsense mediated decay		A0A0G2JGG6	TSL 1: A transcript where all splice junctions are supported by at least one non-suspect mRNA. The Transcript Support Level (TSL) is a method to highlight the well-supported and poorly-supported transcript models for users, based on the type and quality of the alignments used to annotate the transcript. TSL:1,
ENSMUST00000196650.2	Chek2-202	341	No protein	-	Alternatively spliced transcript of a protein coding gene for which we cannot define a CDS.Protein coding CDS not defined		-	TSL 5: A transcript where no single transcript supports the model structure. The Transcript Support Level (TSL) is a method to highlight the well-supported and poorly-supported transcript models for users, based on the type and quality of the alignments used to annotate the transcript. TSL:5,
ENSMUST00000200630.2	Chek2-206	634	No protein	-	An alternatively spliced transcript believed to contain intronic sequence relative to other, coding, transcripts of the same gene.Retained intron		-	TSL 3: A transcript where the only support is from a single EST The Transcript Support Level (TSL) is a method to highlight the well-supported and poorly-supported transcript models for users, based on the type and quality of the alignments used to annotate the transcript. TSL:3,

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Strains

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Genomic alignments

Gene tree

Orthologues

Paralogues (Not available)

Families (Not available)

More views of comparative genomics data, such as multiple alignments and synteny, are available on the Location page for this gene.

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Personal Data