Gene: NEFL ENSG00000277586

Description

neurofilament light chain [Source:HGNC Symbol;Acc:HGNC:7739]

Gene Synonyms

CMT1F, CMT2E, NF68, NFL, PPP1R110

Location

Chromosome 8: 24,950,955-24,956,721 reverse strand.

GRCh38:CM000670.2

About this gene

This gene has 2 transcripts (splice variants), 268 orthologues, 68 paralogues and is associated with 6 phenotypes.

Transcripts

Show transcript tableHide transcript table

Transcript ID	Name	bp	Protein	Translation ID	Biotype	CCDS	UniProt Match	RefSeq Match	Flags
ENST00000610854.2	NEFL-201	3584	543aa	ENSP00000482169.2	Gene/transcipt that contains an open reading frame (ORF).Protein coding	CCDS75712	P07196	NM_006158.5	The Matched Annotation from NCBI and EMBL-EBI is a collaboration between Ensembl/GENCODE and RefSeq. The MANE Select is a default transcript per human gene that is representative of biology, well-supported, expressed and highly-conserved. This transcript set matches GRCh38 and is 100% identical between RefSeq and Ensembl/GENCODE for 5' UTR, CDS, splicing and 3'UTR.MANE Select, A single transcript chosen for a gene which is the most conserved, most highly expressed, has the longest coding sequence and is represented in other key resources, such as NCBI and UniProt. This is defined in detail on http://www.ensembl.org/info/genome/genebuild/canonical.htmlEnsembl Canonical, The GENCODE set is the gene set for human and mouse. GENCODE Basic is a subset of representative transcripts (splice variants).GENCODE basic, APPRIS P1: Transcript(s) expected to code for the main functional isoform based solely on the core modules in the APPRIS. APPRIS is a system to annotate alternatively spliced transcripts based on a range of computational methods to identify the most functionally important transcript(s) of a gene. APPRIS P1, TSL 1: A transcript where all splice junctions are supported by at least one non-suspect mRNA. The Transcript Support Level (TSL) is a method to highlight the well-supported and poorly-supported transcript models for users, based on the type and quality of the alignments used to annotate the transcript. TSL:1,
ENST00000615973.1	NEFL-202	1497	No protein	-	An alternatively spliced transcript believed to contain intronic sequence relative to other, coding, transcripts of the same gene.Retained intron		-	-	TSL NA: A transcript that was not analysed for TSL. The Transcript Support Level (TSL) is a method to highlight the well-supported and poorly-supported transcript models for users, based on the type and quality of the alignments used to annotate the transcript. TSL:NA,

Gene: NEFL ENSG00000277586

Summary

About Us

Get help

Our sister sites

Follow us

Favourite species

All species

Recent locations

Gene: NEFL ENSG00000277586

Summary

About Us

Get help

Our sister sites

Follow us