Description
Cytosolic copper-zinc superoxide dismutase; detoxifies superoxide; stabilizes Yck1p and Yck2p kinases in glucose to repress respiration; phosphorylated by Dun1p, enters nucleus under oxidative stress to promote transcription of stress response genes; human ortholog SOD1 implicated in ALS complements a null allele; abundance increases under DNA replication stress and during exposure to boric acid; localization to mitochondrial intermembrane space is modulated by MICOS complex [Source:SGD;Acc:S000003865]
Gene Synonyms
CRS4
Location
Chromosome X: 622,550-623,014 reverse strand.
R64-1-1:BK006943.2
About this gene
This gene has 1 transcript (splice variant), 8 orthologues and 1 paralogue.
Transcripts
