Highly conserved negative regulator of RNA polymerase III; involved in tRNA processing and stability; inhibits tRNA degradation via rapid tRNA decay (RTD) pathway; binds N-terminal domain of Rpc160p subunit of Pol III to prevent closed-complex formation; regulated by phosphorylation mediated by TORC1, protein kinase A, Sch9p, casein kinase 2; localizes to cytoplasm during vegetative growth and translocates to nucleus and nucleolus under stress conditions [Source:SGD;Acc:S000002412]
Chromosome IV: 456,836-458,103 reverse strand.
R64-1-1:BK006938.2
This gene has 1 transcript (splice variant) and 227 orthologues.
Transcript ID | Name | bp | Protein | Translation ID | Biotype | UniProt Match | Flags |
---|---|---|---|---|---|---|---|
YDR005C_mRNA | MAF1 | 1188 | 395aa | YDR005C | Protein coding | P41910 | Ensembl Canonical, |