Description
RING domain E3 ubiquitin ligase; involved in ubiquitin-mediated degradation of non-stop proteins and translationally stalled ER membrane proteins; component of ribosome-bound RQC (ribosome quality control) complex; degrades products of mRNAs lacking a termination codon regardless of a poly(A) tail; functional connections to chromatin modification; homolog of mouse Listerin, mutations in which reported to cause neurodegeneration [Source:SGD;Acc:S000004861]
Gene Synonyms
LTN1
Location
Chromosome XIII: 763,351-768,039 reverse strand.
R64-1-1:BK006946.2
About this gene
This gene has 1 transcript (splice variant) and 215 orthologues.
Transcripts
