Description
Nuclease subunit of the MRX complex with Rad50p and Xrs2p; complex functions in repair of DNA double-strand breaks and in telomere stability; Mre11p associates with Ser/Thr-rich ORFs in premeiotic phase; nuclease activity required for MRX function; widely conserved; forms nuclear foci upon DNA replication stress [Source:SGD;Acc:S000004837]
Gene Synonyms
NGS1, RAD58, XRS4
Location
Chromosome XIII: 718,575-720,653 reverse strand.
R64-1-1:BK006946.2
About this gene
This gene has 1 transcript (splice variant) and 212 orthologues.
Transcripts
