Description
HMG-CoA reductase; catalyzes conversion of HMG-CoA to mevalonate, which is a rate-limiting step in sterol biosynthesis; one of two isozymes; localizes to nuclear envelope; overproduction induces formation of karmellae; forms foci at nuclear periphery upon DNA replication stress; HMG1 has a paralog, HMG2, that arose from the whole genome duplication; human homolog HMGCR can complement yeast hmg1 mutant [Source:SGD;Acc:S000004540]
Location
Chromosome XIII: 115,734-118,898 reverse strand.
R64-1-1:BK006946.2
About this gene
This gene has 1 transcript (splice variant), 269 orthologues and 1 paralogue.
Transcripts
