Description
Silencing protein; interacts with Sir2p, Sir4p, and histone H3/H4 tails to establish transcriptionally silent chromatin; required for spreading of silenced chromatin; recruited to chromatin through interaction with Rap1p; C-terminus assumes variant winged helix-turn-helix (wH) fold that mediates homodimerization, which is critical for holo-SIR complex loading; required for telomere hypercluster formation in quiescent yeast cells; has paralog ORC1 from whole genome duplication [Source:SGD;Acc:S000004434]
Gene Synonyms
CMT1, MAR2, STE8
Location
Chromosome XII: 1,019,315-1,022,251 reverse strand.
R64-1-1:BK006945.2
About this gene
This gene has 1 transcript (splice variant), 196 orthologues and 2 paralogues.
Transcripts
