Description
Cytoplasmic thioredoxin isoenzyme; part of thioredoxin system which protects cells against oxidative and reductive stress; forms LMA1 complex with Pbi2p; acts as a cofactor for Tsa1p; required for ER-Golgi transport and vacuole inheritance; with Trx2p, facilitates mitochondrial import of small Tims Tim9p, Tim10p, Tim13p by maintaining them in reduced form; abundance increases iunder DNA replication stress; TRX1 has a paralog, TRX2, that arose from the whole genome duplication [Source:SGD;Acc:S000004033]
Gene Synonyms
LMA1
Location
Chromosome XII: 231,702-232,013 reverse strand.
R64-1-1:BK006945.2
About this gene
This gene has 1 transcript (splice variant), 217 orthologues and 2 paralogues.
Transcripts
