Description
DNA helicase/Ubiquitin ligase; involved in error-free DNA damage tolerance (DDT), replication fork regression during postreplication repair by template switching, error-prone translesion synthesis; promotes synthesis of free and PCNA-bound polyubiquitin chains by Ubc13p-Mms2p; forms nuclear foci upon DNA replication stress; associates with native telomeres, cooperates with homologous recombination in senescent cells; human homolog HLTF can complement yeast null mutant [Source:SGD;Acc:S000004022]
Gene Synonyms
REV2, SNM2
Location
Chromosome XII: 204,991-208,500 forward strand.
R64-1-1:BK006945.2
About this gene
This gene has 1 transcript (splice variant), 57 orthologues and 13 paralogues.
Transcripts
