Description
Ubiquitin-protein ligase (E3); controls septin dynamics, spindle position checkpoint (SPOC) with ligase Dma2p by regulating recruitment of Elm1p to bud neck; regulates levels of eIF2 subunit Gcd11p, as well as abundance, localization, and ubiquitination of Cdk inhibitory kinase Swe1p; ubiquitinates cyclin Pcl1p; ortholog of human RNF8, similar to human Chfr; contains FHA, RING fingers; DMA1 has a paralog, DMA2, that arose from the whole genome duplication [Source:SGD;Acc:S000001157]
Gene Synonyms
CHF1
Location
Chromosome VIII: 340,109-341,359 reverse strand.
R64-1-1:BK006934.2
About this gene
This gene has 1 transcript (splice variant) and 1 paralogue.
Transcripts
