Mannosyltransferase in the N-linked glycosylation pathway; catalyzes two consecutive steps in the N-linked glycosylation pathway; alg2 mutants exhibit temperature-sensitive growth and abnormal accumulation of the lipid-linked oligosaccharide Man2GlcNAc2-PP-Dol; human ALG2 complements the temperature sensitivity and dolichol-linked oligosaccharide biosynthesis defect of the alg2-1 mutant, but mutant form from a patient with CDG-Ii fails to complement [Source:SGD;Acc:S000003033]
Chromosome VII: 379,760-381,271 reverse strand.
R64-1-1:BK006941.2
This gene has 1 transcript (splice variant), 198 orthologues and 2 paralogues.
Transcript ID | Name | bp | Protein | Translation ID | Biotype | UniProt Match | Flags |
---|---|---|---|---|---|---|---|
YGL065C_mRNA | ALG2 | 1512 | 503aa | YGL065C | Protein coding | P43636 | Ensembl Canonical, |