Top 40 InterPro Domains in the Ensembl Database

No.

Interpro name	Number of genes	Number of Ensembl hits	No.	Interpro name	Number of genes	Number of Ensembl hits
1	IPR000276 Rhodopsin-like GPCR superfamily	1495	25452	21	IPR002048 Calcium-binding EF-hand	95	1208
2	IPR000694 Proline-rich region	806	14058	22	IPR001304 C-type lectin	94	1066
3	IPR000719 Protein kinase, core	361	7790	23	IPR006907 Protein of unknown function DUF622	89	197
4	IPR003596 Immunoglobulin V-set, subgroup	359	5111	24	IPR000048 IQ calmodulin-binding region	87	3782
5	IPR000504 RNA recognition motif, RNP-1	260	3311	25	IPR001128 Cytochrome P450	84	3964
6	IPR000533 Tropomyosin	184	2295	26	IPR000152 Aspartic acid and asparagine hydroxylation site	83	10440
7	IPR000210 BTB/POZ-like	182	4865	27	IPR001440 Tetratricopeptide TPR-1	81	2037
8	IPR001680 WD40 repeat	174	3725	28	IPR001092 Basic helix-loop-helix dimerisation region bHLH	80	502
9	IPR000047 Helix-turn-helix motif, lambda-like repressor	145	2180	29	IPR000068 GPCR, family 3, extracellular calcium-sensing receptor-related	77	6785
10	IPR000104 Antifreeze protein, type I	138	2708	30	IPR002345 Lipocalin	72	187
11	IPR000008 C2 calcium-dependent membrane targeting	133	4113	31	IPR000169 Peptidase, cysteine peptidase active site	71	1312
12	IPR000173 Glyceraldehyde 3-phosphate dehydrogenase	131	910	32	IPR000198 RhoGAP	68	1120
13	IPR001806 Ras GTPase	118	1896	33	IPR000372 Leucine-rich repeat, cysteine-rich flanking region, N-terminal	67	1964
14	IPR001841 Zinc finger, RING-type	117	1014	34	IPR000626 Ubiquitin	66	457
15	IPR001781 Zinc finger, LIM-type	112	5955	35	IPR002126 Cadherin	66	2833
16	IPR001909 KRAB box	111	4681	36	IPR000357 HEAT	63	446
17	IPR000135 High mobility group box, HMG1/HMG2, subgroup	107	1916	37	IPR000742 EGF-like, type 3	62	2367
18	IPR001254 Peptidase S1 and S6, chymotrypsin/Hap	105	1198	38	IPR000108 Neutrophil cytosol factor 2	60	2916
19	IPR002110 Ankyrin	100	2729	39	IPR000315 Zinc finger, B-box	58	1655
20	IPR001611 Leucine-rich repeat	96	1527	40	IPR001478 PDZ/DHR/GLGF	58	1196

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