Top 40 InterPro Domains in the Ensembl Database

No.

Interpro name	Number of genes	Number of Ensembl hits	No.	Interpro name	Number of genes	Number of Ensembl hits
1	IPR000694 Proline-rich region	1185	24842	21	IPR000048 IQ calmodulin-binding region	91	4621
2	IPR000276 Rhodopsin-like GPCR superfamily	702	15535	22	IPR001440 Tetratricopeptide TPR-1	89	3545
3	IPR003596 Immunoglobulin V-set, subgroup	381	6599	23	IPR000108 Neutrophil cytosol factor 2	78	6239
4	IPR000719 Protein kinase, core	324	12158	24	IPR001254 Peptidase S1 and S6, chymotrypsin/Hap	77	1101
5	IPR000504 RNA recognition motif, RNP-1	225	3926	25	IPR000372 Leucine-rich repeat, cysteine-rich flanking region, N-terminal	74	2944
6	IPR000533 Tropomyosin	223	4628	26	IPR007086 Zinc finger, C2H2-subtype	70	2192
7	IPR001909 KRAB box	209	14188	27	IPR001128 Cytochrome P450	70	2785
8	IPR001781 Zinc finger, LIM-type	198	15419	28	IPR003598 Immunoglobulin subtype 2	70	2013
9	IPR000104 Antifreeze protein, type I	191	5668	29	IPR001092 Basic helix-loop-helix dimerisation region bHLH	69	614
10	IPR001680 WD40 repeat	182	6268	30	IPR002126 Cadherin	66	4544
11	IPR000210 BTB/POZ-like	177	5919	31	IPR000742 EGF-like, type 3	65	4681
12	IPR000047 Helix-turn-helix motif, lambda-like repressor	157	3117	32	IPR000637 HMG-I and HMG-Y, DNA-binding	63	1663
13	IPR001841 Zinc finger, RING-type	143	1785	33	IPR000357 HEAT	61	684
14	IPR000008 C2 calcium-dependent membrane targeting	140	5863	34	IPR000198 RhoGAP	60	1329
15	IPR001806 Ras GTPase	129	2623	35	IPR001304 C-type lectin	59	895
16	IPR002110 Ankyrin	111	4409	36	IPR000225 Armadillo	59	1603
17	IPR001611 Leucine-rich repeat	102	2409	37	IPR000195 RabGAP/TBC	56	744
18	IPR000315 Zinc finger, B-box	98	3438	38	IPR001478 PDZ/DHR/GLGF	55	1870
19	IPR000152 Aspartic acid and asparagine hydroxylation site	96	14914	39	IPR001394 Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2	54	601
20	IPR002048 Calcium-binding EF-hand	91	1520	40	IPR000219 DH	54	1847

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