Description

serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1 [Source:HGNC Symbol;Acc:HGNC:8941]

Synonyms

A1A, A1AT, AAT, alpha-1-antitrypsin, alpha1AT, PI, PI1

Location
Gene

This transcript is a product of gene ENSG00000197249

This gene has 19 transcripts (splice variants) Show transcript tableHide transcript table

NameTranscript IDbpProteinBiotypeCCDSUniProtRefSeqFlags
SERPINA1-203ENST000004489213532418 aa
 
Protein codingGenes and/or transcript that contains an open reading frame (ORF).
CCDS9925A6YP93 E9KL23 G3V2B9
G3V387 G3V4I7 G3V544
G3V5R8 P01009 Q3I0J7
NM_001002236
NM_001127701
NM_001127703
NM_001127704
NM_001127705
NP_001002236
NP_001121173
NP_001121175
NP_001121176
NP_001121177
TSL:5

TSL5: No single transcript (mRNA or EST) supports this transcript model's structure.

The Transcript Support Level (TSL) is a method to highlight the well-supported and poorly-supported transcript models for users. The method relies on the primary data that can support full-length transcript structure: mRNA and EST alignments supplied by UCSC and Ensembl.

GENCODE basicThe GENCODE set is the gene set for human and mouse. GENCODE Basic is a subset of representative transcripts (splice variants).APPRIS PIAPPRIS principal isoform
Glossary entry for APPRIS
APPRIS website
SERPINA1-202ENST000004373973340418 aa
 
Protein codingGenes and/or transcript that contains an open reading frame (ORF).
CCDS9925A6YP93 E9KL23 G3V2B9
G3V387 G3V4I7 G3V544
G3V5R8 P01009 Q3I0J7
NM_001127702
NM_001127706
NM_001127707
NP_001121174
NP_001121178
NP_001121179
TSL:5

TSL5: No single transcript (mRNA or EST) supports this transcript model's structure.

The Transcript Support Level (TSL) is a method to highlight the well-supported and poorly-supported transcript models for users. The method relies on the primary data that can support full-length transcript structure: mRNA and EST alignments supplied by UCSC and Ensembl.

GENCODE basicThe GENCODE set is the gene set for human and mouse. GENCODE Basic is a subset of representative transcripts (splice variants).APPRIS PIAPPRIS principal isoform
Glossary entry for APPRIS
APPRIS website
SERPINA1-201ENST000003558143236418 aa
 
Protein codingGenes and/or transcript that contains an open reading frame (ORF).
CCDS9925A6YP93 E9KL23 G3V2B9
G3V387 G3V4I7 G3V544
G3V5R8 P01009 Q3I0J7
NM_001002235
NM_001127700
NP_001002235
NP_001121172
TSL:5

TSL5: No single transcript (mRNA or EST) supports this transcript model's structure.

The Transcript Support Level (TSL) is a method to highlight the well-supported and poorly-supported transcript models for users. The method relies on the primary data that can support full-length transcript structure: mRNA and EST alignments supplied by UCSC and Ensembl.

GENCODE basicThe GENCODE set is the gene set for human and mouse. GENCODE Basic is a subset of representative transcripts (splice variants).APPRIS PIAPPRIS principal isoform
Glossary entry for APPRIS
APPRIS website
SERPINA1-001ENST000004409093144418 aa
 
Protein codingGenes and/or transcript that contains an open reading frame (ORF).
CCDS9925A6YP93 E9KL23 G3V2B9
G3V387 G3V4I7 G3V544
G3V5R8 P01009 Q3I0J7
-TSL:1

TSL1: All splice junctions of the transcript are supported by at least one non-suspect mRNA.

The Transcript Support Level (TSL) is a method to highlight the well-supported and poorly-supported transcript models for users. The method relies on the primary data that can support full-length transcript structure: mRNA and EST alignments supplied by UCSC and Ensembl.

GENCODE basicThe GENCODE set is the gene set for human and mouse. GENCODE Basic is a subset of representative transcripts (splice variants).APPRIS PIAPPRIS principal isoform
Glossary entry for APPRIS
APPRIS website
SERPINA1-002ENST000003930881885418 aa
 
Protein codingGenes and/or transcript that contains an open reading frame (ORF).
CCDS9925A6YP93 E9KL23 G3V2B9
G3V387 G3V4I7 G3V544
G3V5R8 P01009 Q3I0J7
-TSL:1

TSL1: All splice junctions of the transcript are supported by at least one non-suspect mRNA.

The Transcript Support Level (TSL) is a method to highlight the well-supported and poorly-supported transcript models for users. The method relies on the primary data that can support full-length transcript structure: mRNA and EST alignments supplied by UCSC and Ensembl.

GENCODE basicThe GENCODE set is the gene set for human and mouse. GENCODE Basic is a subset of representative transcripts (splice variants).APPRIS PIAPPRIS principal isoform
Glossary entry for APPRIS
APPRIS website
SERPINA1-003ENST000004048141628418 aa
 
Protein codingGenes and/or transcript that contains an open reading frame (ORF).
CCDS9925A6YP93 E9KL23 G3V2B9
G3V387 G3V4I7 G3V544
G3V5R8 P01009 Q3I0J7
-TSL:5

TSL5: No single transcript (mRNA or EST) supports this transcript model's structure.

The Transcript Support Level (TSL) is a method to highlight the well-supported and poorly-supported transcript models for users. The method relies on the primary data that can support full-length transcript structure: mRNA and EST alignments supplied by UCSC and Ensembl.

GENCODE basicThe GENCODE set is the gene set for human and mouse. GENCODE Basic is a subset of representative transcripts (splice variants).APPRIS PIAPPRIS principal isoform
Glossary entry for APPRIS
APPRIS website
SERPINA1-004ENST000003930871622418 aa
 
Protein codingGenes and/or transcript that contains an open reading frame (ORF).
CCDS9925A6YP93 E9KL23 G3V2B9
G3V387 G3V4I7 G3V544
G3V5R8 P01009 Q3I0J7
NM_000295
NP_000286
TSL:1

TSL1: All splice junctions of the transcript are supported by at least one non-suspect mRNA.

The Transcript Support Level (TSL) is a method to highlight the well-supported and poorly-supported transcript models for users. The method relies on the primary data that can support full-length transcript structure: mRNA and EST alignments supplied by UCSC and Ensembl.

GENCODE basicThe GENCODE set is the gene set for human and mouse. GENCODE Basic is a subset of representative transcripts (splice variants).APPRIS PIAPPRIS principal isoform
Glossary entry for APPRIS
APPRIS website
SERPINA1-008ENST000004493991559418 aa
 
Protein codingGenes and/or transcript that contains an open reading frame (ORF).
CCDS9925A6YP93 E9KL23 G3V2B9
G3V387 G3V4I7 G3V544
G3V5R8 P01009 Q3I0J7
-TSL:1

TSL1: All splice junctions of the transcript are supported by at least one non-suspect mRNA.

The Transcript Support Level (TSL) is a method to highlight the well-supported and poorly-supported transcript models for users. The method relies on the primary data that can support full-length transcript structure: mRNA and EST alignments supplied by UCSC and Ensembl.

GENCODE basicThe GENCODE set is the gene set for human and mouse. GENCODE Basic is a subset of representative transcripts (splice variants).APPRIS PIAPPRIS principal isoform
Glossary entry for APPRIS
APPRIS website
SERPINA1-006ENST000004026291450359 aa
 
Protein codingGenes and/or transcript that contains an open reading frame (ORF).
-A6YP93 G3V2B9 G3V387
G3V4I7 G3V544 G3V5R8
P01009 Q3I0J7
-TSL:1

TSL1: All splice junctions of the transcript are supported by at least one non-suspect mRNA.

The Transcript Support Level (TSL) is a method to highlight the well-supported and poorly-supported transcript models for users. The method relies on the primary data that can support full-length transcript structure: mRNA and EST alignments supplied by UCSC and Ensembl.

GENCODE basicThe GENCODE set is the gene set for human and mouse. GENCODE Basic is a subset of representative transcripts (splice variants).
SERPINA1-007ENST00000557492951144 aa
 
Protein codingGenes and/or transcript that contains an open reading frame (ORF).
-G3V387 G3V4I7 G3V5R8
-CDS 3' incomplete3' truncation in transcript evidence prevents annotation of the end of the CDS.TSL:4

TSL4:The best supporting EST for this transcript is flagged as suspect.

The Transcript Support Level (TSL) is a method to highlight the well-supported and poorly-supported transcript models for users. The method relies on the primary data that can support full-length transcript structure: mRNA and EST alignments supplied by UCSC and Ensembl.

SERPINA1-017ENST00000556091643156 aa
 
Protein codingGenes and/or transcript that contains an open reading frame (ORF).
-G3V387 G3V4I7 G3V544
G3V5R8
-CDS 3' incomplete3' truncation in transcript evidence prevents annotation of the end of the CDS.TSL:3

TSL3:The only support for this transcript is from a single EST.

The Transcript Support Level (TSL) is a method to highlight the well-supported and poorly-supported transcript models for users. The method relies on the primary data that can support full-length transcript structure: mRNA and EST alignments supplied by UCSC and Ensembl.

SERPINA1-010ENST0000055711858322 aa
 
Protein codingGenes and/or transcript that contains an open reading frame (ORF).
-G3V4I7 -CDS 3' incomplete3' truncation in transcript evidence prevents annotation of the end of the CDS.TSL:4

TSL4:The best supporting EST for this transcript is flagged as suspect.

The Transcript Support Level (TSL) is a method to highlight the well-supported and poorly-supported transcript models for users. The method relies on the primary data that can support full-length transcript structure: mRNA and EST alignments supplied by UCSC and Ensembl.

SERPINA1-015ENST0000055332758192 aa
 
Protein codingGenes and/or transcript that contains an open reading frame (ORF).
-G3V4I7 G3V5R8 -CDS 3' incomplete3' truncation in transcript evidence prevents annotation of the end of the CDS.TSL:3

TSL3:The only support for this transcript is from a single EST.

The Transcript Support Level (TSL) is a method to highlight the well-supported and poorly-supported transcript models for users. The method relies on the primary data that can support full-length transcript structure: mRNA and EST alignments supplied by UCSC and Ensembl.

SERPINA1-011ENST00000556955571117 aa
 
Protein codingGenes and/or transcript that contains an open reading frame (ORF).
-G3V387 G3V4I7 G3V5R8
-CDS 3' incomplete3' truncation in transcript evidence prevents annotation of the end of the CDS.TSL:4

TSL4:The best supporting EST for this transcript is flagged as suspect.

The Transcript Support Level (TSL) is a method to highlight the well-supported and poorly-supported transcript models for users. The method relies on the primary data that can support full-length transcript structure: mRNA and EST alignments supplied by UCSC and Ensembl.

SERPINA1-016ENST00000554720446105 aa
 
Protein codingGenes and/or transcript that contains an open reading frame (ORF).
-G3V2B9 -CDS 3' incomplete3' truncation in transcript evidence prevents annotation of the end of the CDS.TSL:5

TSL5: No single transcript (mRNA or EST) supports this transcript model's structure.

The Transcript Support Level (TSL) is a method to highlight the well-supported and poorly-supported transcript models for users. The method relies on the primary data that can support full-length transcript structure: mRNA and EST alignments supplied by UCSC and Ensembl.

SERPINA1-005ENST000004897691562306 aa
 
Nonsense mediated decayTranscript is thought to undergo nonsense mediated decay, a process which detects nonsense mutations and prevents the expression of truncated or erroneous proteins.
-A6YP93 G3V2B9 G3V387
G3V4I7 G3V544 G3V5R8
P01009 Q3I0J7
-TSL:1

TSL1: All splice junctions of the transcript are supported by at least one non-suspect mRNA.

The Transcript Support Level (TSL) is a method to highlight the well-supported and poorly-supported transcript models for users. The method relies on the primary data that can support full-length transcript structure: mRNA and EST alignments supplied by UCSC and Ensembl.

SERPINA1-014ENST00000555289609No protein
 
Processed transcriptTranscripts that don't contain an open reading frame (ORF) and cannot be placed in one of the other categories.
---TSL:5

TSL5: No single transcript (mRNA or EST) supports this transcript model's structure.

The Transcript Support Level (TSL) is a method to highlight the well-supported and poorly-supported transcript models for users. The method relies on the primary data that can support full-length transcript structure: mRNA and EST alignments supplied by UCSC and Ensembl.

SERPINA1-012ENST00000557093568No protein
 
Processed transcriptTranscripts that don't contain an open reading frame (ORF) and cannot be placed in one of the other categories.
---TSL:4

TSL4:The best supporting EST for this transcript is flagged as suspect.

The Transcript Support Level (TSL) is a method to highlight the well-supported and poorly-supported transcript models for users. The method relies on the primary data that can support full-length transcript structure: mRNA and EST alignments supplied by UCSC and Ensembl.

SERPINA1-013ENST00000557361580No protein
 
Retained intronAlternatively spliced transcript that is believed to contain intronic sequence relative to other coding transcripts in a given locus.
---TSL:5

TSL5: No single transcript (mRNA or EST) supports this transcript model's structure.

The Transcript Support Level (TSL) is a method to highlight the well-supported and poorly-supported transcript models for users. The method relies on the primary data that can support full-length transcript structure: mRNA and EST alignments supplied by UCSC and Ensembl.

Statistics

Exons: 6 Coding exons: 4 Transcript length: 3,340 bps Translation length: 418 residues

CCDS

This transcript is a member of the Human CCDS set: CCDS9925

Uniprot

This transcript corresponds to the following Uniprot identifiers: P01009

Transcript Support Level

5

Ensembl version

ENST00000437397.3

Type

Known protein coding

Prediction Method

Annotation produced by the Ensembl genebuild.

GENCODE basic gene

This transcript is a member of the Gencode basic gene set.

Transcript-based displays