Description

neurofibromin 2 (merlin) [Source:HGNC Symbol;Acc:HGNC:7773]

Synonyms

merlin

Location
About this transcript

This transcript has 8 exons, is annotated with 8 domains and features, is associated with 398 variations and maps to 10 oligo probes.

Gene
NameTranscript IDbpProteinTranslation IDBiotypeCCDSUniProtRefSeqFlags
NF2-001ENST000003386416025595aaENSP00000344666
 
Protein codingGenes and/or transcript that contains an open reading frame (ORF).
CCDS13861A0A024R1J8 P35240 NM_000268
NP_000259
TSL:1

TSL1: All splice junctions of the transcript are supported by at least one non-suspect mRNA.

The Transcript Support Level (TSL) is a method to highlight the well-supported and poorly-supported transcript models for users. The method relies on the primary data that can support full-length transcript structure: mRNA and EST alignments supplied by UCSC and Ensembl.

GENCODE basicThe GENCODE set is the gene set for human and mouse. GENCODE Basic is a subset of representative transcripts (splice variants).APPRIS PI1APPRIS principal isoform
Glossary entry for APPRIS
APPRIS website
NF2-010ENST000003614525884549aaENSP00000354897
 
Protein codingGenes and/or transcript that contains an open reading frame (ORF).
CCDS13864A0A024R1F6 P35240 NM_181829
NP_861967
TSL:1

TSL1: All splice junctions of the transcript are supported by at least one non-suspect mRNA.

The Transcript Support Level (TSL) is a method to highlight the well-supported and poorly-supported transcript models for users. The method relies on the primary data that can support full-length transcript structure: mRNA and EST alignments supplied by UCSC and Ensembl.

GENCODE basicThe GENCODE set is the gene set for human and mouse. GENCODE Basic is a subset of representative transcripts (splice variants).
NF2-201ENST000004132094733165aaENSP00000409921
 
Protein codingGenes and/or transcript that contains an open reading frame (ORF).
CCDS54516P35240 NM_181833
NP_861971
TSL:1

TSL1: All splice junctions of the transcript are supported by at least one non-suspect mRNA.

The Transcript Support Level (TSL) is a method to highlight the well-supported and poorly-supported transcript models for users. The method relies on the primary data that can support full-length transcript structure: mRNA and EST alignments supplied by UCSC and Ensembl.

GENCODE basicThe GENCODE set is the gene set for human and mouse. GENCODE Basic is a subset of representative transcripts (splice variants).
NF2-003ENST000004039992999590aaENSP00000384797
 
Protein codingGenes and/or transcript that contains an open reading frame (ORF).
CCDS13862A0A024R1J9 P35240 NM_181825
NP_861546
TSL:1

TSL1: All splice junctions of the transcript are supported by at least one non-suspect mRNA.

The Transcript Support Level (TSL) is a method to highlight the well-supported and poorly-supported transcript models for users. The method relies on the primary data that can support full-length transcript structure: mRNA and EST alignments supplied by UCSC and Ensembl.

GENCODE basicThe GENCODE set is the gene set for human and mouse. GENCODE Basic is a subset of representative transcripts (splice variants).
NF2-008ENST000003349612020507aaENSP00000335652
 
Protein codingGenes and/or transcript that contains an open reading frame (ORF).
CCDS13865A0A024R1D9 P35240 NM_181831
NP_861969
TSL:1

TSL1: All splice junctions of the transcript are supported by at least one non-suspect mRNA.

The Transcript Support Level (TSL) is a method to highlight the well-supported and poorly-supported transcript models for users. The method relies on the primary data that can support full-length transcript structure: mRNA and EST alignments supplied by UCSC and Ensembl.

GENCODE basicThe GENCODE set is the gene set for human and mouse. GENCODE Basic is a subset of representative transcripts (splice variants).
NF2-009ENST000003977891857590aaENSP00000380891
 
Protein codingGenes and/or transcript that contains an open reading frame (ORF).
CCDS13862A0A024R1J9 P35240 NM_181832
NP_861970
TSL:1

TSL1: All splice junctions of the transcript are supported by at least one non-suspect mRNA.

The Transcript Support Level (TSL) is a method to highlight the well-supported and poorly-supported transcript models for users. The method relies on the primary data that can support full-length transcript structure: mRNA and EST alignments supplied by UCSC and Ensembl.

GENCODE basicThe GENCODE set is the gene set for human and mouse. GENCODE Basic is a subset of representative transcripts (splice variants).
NF2-005ENST000003538871845507aaENSP00000340626
 
Protein codingGenes and/or transcript that contains an open reading frame (ORF).
CCDS13865A0A024R1D9 P35240 NM_181830
NP_861968
TSL:1

TSL1: All splice junctions of the transcript are supported by at least one non-suspect mRNA.

The Transcript Support Level (TSL) is a method to highlight the well-supported and poorly-supported transcript models for users. The method relies on the primary data that can support full-length transcript structure: mRNA and EST alignments supplied by UCSC and Ensembl.

GENCODE basicThe GENCODE set is the gene set for human and mouse. GENCODE Basic is a subset of representative transcripts (splice variants).
NF2-007ENST000003611661837590aaENSP00000354529
 
Protein codingGenes and/or transcript that contains an open reading frame (ORF).
CCDS13862A0A024R1J9 P35240 NM_016418
NP_057502
TSL:1

TSL1: All splice junctions of the transcript are supported by at least one non-suspect mRNA.

The Transcript Support Level (TSL) is a method to highlight the well-supported and poorly-supported transcript models for users. The method relies on the primary data that can support full-length transcript structure: mRNA and EST alignments supplied by UCSC and Ensembl.

GENCODE basicThe GENCODE set is the gene set for human and mouse. GENCODE Basic is a subset of representative transcripts (splice variants).
NF2-006ENST000003616761716548aaENSP00000355183
 
Protein codingGenes and/or transcript that contains an open reading frame (ORF).
CCDS13863A0A024R1I0 P35240 NM_181828
NP_861966
TSL:1

TSL1: All splice junctions of the transcript are supported by at least one non-suspect mRNA.

The Transcript Support Level (TSL) is a method to highlight the well-supported and poorly-supported transcript models for users. The method relies on the primary data that can support full-length transcript structure: mRNA and EST alignments supplied by UCSC and Ensembl.

GENCODE basicThe GENCODE set is the gene set for human and mouse. GENCODE Basic is a subset of representative transcripts (splice variants).
NF2-004ENST000004034352568561aaENSP00000384029
 
Protein codingGenes and/or transcript that contains an open reading frame (ORF).
-P35240 -TSL:5

TSL5: No single transcript (mRNA or EST) supports this transcript model's structure.

The Transcript Support Level (TSL) is a method to highlight the well-supported and poorly-supported transcript models for users. The method relies on the primary data that can support full-length transcript structure: mRNA and EST alignments supplied by UCSC and Ensembl.

GENCODE basicThe GENCODE set is the gene set for human and mouse. GENCODE Basic is a subset of representative transcripts (splice variants).
NF2-002ENST000004321511000220aaENSP00000395885
 
Nonsense mediated decayTranscript is thought to undergo nonsense mediated decay, a process which detects nonsense mutations and prevents the expression of truncated or erroneous proteins.
-P35240 -TSL:1

TSL1: All splice junctions of the transcript are supported by at least one non-suspect mRNA.

The Transcript Support Level (TSL) is a method to highlight the well-supported and poorly-supported transcript models for users. The method relies on the primary data that can support full-length transcript structure: mRNA and EST alignments supplied by UCSC and Ensembl.

Statistics

Exons: 8 Coding exons: 7 Transcript length: 1,000 bps Translation length: 220 residues

Uniprot

This transcript corresponds to the following Uniprot identifiers: P35240

Transcript Support Level (TSL)

TSL:1

Ensembl version

ENST00000432151.4

Type

Known nonsense mediated decay

Annotation Method

Manual annotation (determined on a case-by-case basis) from the Havana project.

Alternative transcripts

This transcript corresponds to the following database identifiers:

Havana transcript:

Transcript-based displays