Description

inducible T-cell co-stimulator ligand [Source:HGNC Symbol;Acc:HGNC:17087]

Synonyms

B7-H2, B7H2, B7RP-1, B7RP1, CD275, GL50, ICOS-L, ICOSL, KIAA0653

Location
About this transcript

This transcript has 7 exons, is annotated with 13 domains and features, is associated with 123 variations and maps to 16 oligo probes.

Gene
NameTranscript IDbpProteinTranslation IDBiotypeCCDSUniProtRefSeqFlags
ICOSLG-001ENST000004077807080302aaENSP00000384432
 
Protein codingGenes and/or transcript that contains an open reading frame (ORF).
CCDS42952A0N0L8 O75144 NM_001283052
NM_015259
NP_001269981
NP_056074
TSL:1

Transcript Support Level 1, when transcripts are supported by at least one non-suspect mRNA.

The Transcript Support Level (TSL) is a method to highlight the well-supported and poorly-supported transcript models for users. The method relies on the primary data that can support full-length transcript structure: mRNA and EST alignments supplied by UCSC and Ensembl.

GENCODE basicThe GENCODE set is the gene set for human and mouse. GENCODE Basic is a subset of representative transcripts (splice variants).APPRIS P3

PRINCIPAL3 - APPRIS candidate principal isoform (earliest CCDS).

APPRIS is a system to annotate alternatively spliced transcripts based on a range of computational methods.

ICOSLG-002ENST000004003772907185aaENSP00000383228
 
Protein codingGenes and/or transcript that contains an open reading frame (ORF).
CCDS63377O75144 NM_001283051
NP_001269980
TSL:2

Transcript Support Level 2, when transcripts are supported by multiple ESTs or by an mRNA flagged as suspect.

The Transcript Support Level (TSL) is a method to highlight the well-supported and poorly-supported transcript models for users. The method relies on the primary data that can support full-length transcript structure: mRNA and EST alignments supplied by UCSC and Ensembl.

GENCODE basicThe GENCODE set is the gene set for human and mouse. GENCODE Basic is a subset of representative transcripts (splice variants).
ICOSLG-003ENST000003443301009309aaENSP00000339477
 
Protein codingGenes and/or transcript that contains an open reading frame (ORF).
CCDS63379O75144 NM_001283050
NP_001269979
TSL:1

Transcript Support Level 1, when transcripts are supported by at least one non-suspect mRNA.

The Transcript Support Level (TSL) is a method to highlight the well-supported and poorly-supported transcript models for users. The method relies on the primary data that can support full-length transcript structure: mRNA and EST alignments supplied by UCSC and Ensembl.

GENCODE basicThe GENCODE set is the gene set for human and mouse. GENCODE Basic is a subset of representative transcripts (splice variants).APPRIS ALT2

ALTERNATIVE2 - APPRIS candidate principal isoform that appears to be conserved in fewer than three tested non-primate species.

APPRIS is a system to annotate alternatively spliced transcripts based on a range of computational methods.

ICOSLG-004ENST000004003794246473aaENSP00000383230
 
Protein codingGenes and/or transcript that contains an open reading frame (ORF).
-K4DIA0 -TSL:1

Transcript Support Level 1, when transcripts are supported by at least one non-suspect mRNA.

The Transcript Support Level (TSL) is a method to highlight the well-supported and poorly-supported transcript models for users. The method relies on the primary data that can support full-length transcript structure: mRNA and EST alignments supplied by UCSC and Ensembl.

GENCODE basicThe GENCODE set is the gene set for human and mouse. GENCODE Basic is a subset of representative transcripts (splice variants).APPRIS ALT2

ALTERNATIVE2 - APPRIS candidate principal isoform that appears to be conserved in fewer than three tested non-primate species.

APPRIS is a system to annotate alternatively spliced transcripts based on a range of computational methods.

Statistics

Exons: 7 Coding exons: 7 Transcript length: 1,009 bps Translation length: 309 residues

CCDS

This transcript is a member of the Human CCDS set: CCDS63379

Uniprot

This transcript corresponds to the following Uniprot identifiers: O75144

Transcript Support Level (TSL)

TSL:1

Ensembl version

ENST00000344330.7

Type

Known protein coding

Annotation Method

Transcript where the Ensembl genebuild transcript and the Vega manual annotation have the same sequence, for every base pair. See article.

Alternative transcripts

This transcript corresponds to the following database identifiers:

Havana transcript:
GENCODE basic gene

This transcript is a member of the Gencode basic gene set.

Transcript-based displays