Description

cholinergic receptor, nicotinic, alpha 1 (muscle) [Source:HGNC Symbol;Acc:HGNC:1955]

Synonyms

CHRNA

About this transcript

This transcript has 9 exons, is annotated with 22 domains and features, is associated with 224 variations and maps to 12 oligo probes.

Gene
NameTranscript IDbpProteinTranslation IDBiotypeCCDSUniProtRefSeqFlags
CHRNA1-001ENST000003487491984457aaENSP00000261008
 
Protein codingGenes and/or transcript that contains an open reading frame (ORF).
CCDS2261P02708 Q53SH4 NM_000079
NP_000070
TSL:1

TSL1: All splice junctions of the transcript are supported by at least one non-suspect mRNA.

The Transcript Support Level (TSL) is a method to highlight the well-supported and poorly-supported transcript models for users. The method relies on the primary data that can support full-length transcript structure: mRNA and EST alignments supplied by UCSC and Ensembl.

GENCODE basicThe GENCODE set is the gene set for human and mouse. GENCODE Basic is a subset of representative transcripts (splice variants).APPRIS PI1APPRIS principal isoform
Glossary entry for APPRIS
APPRIS website
CHRNA1-002ENST000002610071980482aaENSP00000261007
 
Protein codingGenes and/or transcript that contains an open reading frame (ORF).
CCDS33331P02708 NM_001039523
NP_001034612
TSL:2

TSL2: The best supporting mRNA is flagged as suspect or the support is from multiple ESTs.

The Transcript Support Level (TSL) is a method to highlight the well-supported and poorly-supported transcript models for users. The method relies on the primary data that can support full-length transcript structure: mRNA and EST alignments supplied by UCSC and Ensembl.

GENCODE basicThe GENCODE set is the gene set for human and mouse. GENCODE Basic is a subset of representative transcripts (splice variants).
CHRNA1-004ENST000004093231585269aaENSP00000386684
 
Protein codingGenes and/or transcript that contains an open reading frame (ORF).
-G5E9G9 -TSL:1

TSL1: All splice junctions of the transcript are supported by at least one non-suspect mRNA.

The Transcript Support Level (TSL) is a method to highlight the well-supported and poorly-supported transcript models for users. The method relies on the primary data that can support full-length transcript structure: mRNA and EST alignments supplied by UCSC and Ensembl.

GENCODE basicThe GENCODE set is the gene set for human and mouse. GENCODE Basic is a subset of representative transcripts (splice variants).
CHRNA1-005ENST000004092191466377aaENSP00000386611
 
Protein codingGenes and/or transcript that contains an open reading frame (ORF).
-E7ENE5 -TSL:3

TSL3:The only support for this transcript is from a single EST.

The Transcript Support Level (TSL) is a method to highlight the well-supported and poorly-supported transcript models for users. The method relies on the primary data that can support full-length transcript structure: mRNA and EST alignments supplied by UCSC and Ensembl.

GENCODE basicThe GENCODE set is the gene set for human and mouse. GENCODE Basic is a subset of representative transcripts (splice variants).
CHRNA1-003ENST000004095421460375aaENSP00000387026
 
Protein codingGenes and/or transcript that contains an open reading frame (ORF).
-B8ZZD3 -TSL:3

TSL3:The only support for this transcript is from a single EST.

The Transcript Support Level (TSL) is a method to highlight the well-supported and poorly-supported transcript models for users. The method relies on the primary data that can support full-length transcript structure: mRNA and EST alignments supplied by UCSC and Ensembl.

GENCODE basicThe GENCODE set is the gene set for human and mouse. GENCODE Basic is a subset of representative transcripts (splice variants).
CHRNA1-006ENST00000435083159681aaENSP00000395805
 
Nonsense mediated decayTranscript is thought to undergo nonsense mediated decay, a process which detects nonsense mutations and prevents the expression of truncated or erroneous proteins.
-F8WDS3 -TSL:3

TSL3:The only support for this transcript is from a single EST.

The Transcript Support Level (TSL) is a method to highlight the well-supported and poorly-supported transcript models for users. The method relies on the primary data that can support full-length transcript structure: mRNA and EST alignments supplied by UCSC and Ensembl.

Statistics

Exons: 9 Coding exons: 9 Transcript length: 1,984 bps Translation length: 457 residues

CCDS

This transcript is a member of the Human CCDS set: CCDS2261

Uniprot

This transcript corresponds to the following Uniprot identifiers: P02708

Transcript Support Level (TSL)

TSL:1

Ensembl version

ENST00000348749.8

Type

Known protein coding

Annotation Method

Transcript where the Ensembl genebuild transcript and the Vega manual annotation have the same sequence, for every base pair. See article.

Alternative transcripts

This transcript corresponds to the following database identifiers:

Havana transcript:
GENCODE basic gene

This transcript is a member of the Gencode basic gene set.

Transcript-based displays