Description

pyruvate kinase, muscle [Source:HGNC Symbol;Acc:HGNC:9021]

Synonyms

OIP3, PK3, PKM2, THBP1

Location
Gene

This transcript is a product of gene ENSG00000067225

This gene has 25 transcripts (splice variants) Show transcript tableHide transcript table

NameTranscript IDbpProteinBiotypeCCDSUniProtRefSeqFlags
PKM-201ENST000003196222717531 aa
 
Protein codingGenes and/or transcript that contains an open reading frame (ORF).
CCDS32285A0A024R5Z9 H3BN34 H3BT25
H3BTJ2 H3BTN5 H3BU13
H3BUW1 P14618 PKM2-201
NM_001206796
NM_182470
NM_182471
NP_001193725
NP_872270
NP_872271
TSL:2

TSL2: The best supporting mRNA is flagged as suspect or the support is from multiple ESTs.

The Transcript Support Level (TSL) is a method to highlight the well-supported and poorly-supported transcript models for users. The method relies on the primary data that can support full-length transcript structure: mRNA and EST alignments supplied by UCSC and Ensembl.

GENCODE basicThe GENCODE set is the gene set for human and mouse. GENCODE Basic is a subset of representative transcripts (splice variants).APPRIS CI1APPRIS candidate principal isoform (longest coding sequence) [01-09-2014]
Glossary entry for APPRIS
APPRIS website
PKM-203ENST000004499012526516 aa
 
Protein codingGenes and/or transcript that contains an open reading frame (ORF).
CCDS55972P14618 PKM2-203 Q8WUW7
Q9UKK4
NM_001206798
NP_001193727
TSL:2

TSL2: The best supporting mRNA is flagged as suspect or the support is from multiple ESTs.

The Transcript Support Level (TSL) is a method to highlight the well-supported and poorly-supported transcript models for users. The method relies on the primary data that can support full-length transcript structure: mRNA and EST alignments supplied by UCSC and Ensembl.

GENCODE basicThe GENCODE set is the gene set for human and mouse. GENCODE Basic is a subset of representative transcripts (splice variants).
PKM-012ENST000005651842503531 aa
 
Protein codingGenes and/or transcript that contains an open reading frame (ORF).
CCDS32285A0A024R5Z9 H3BN34 H3BT25
H3BTJ2 H3BTN5 H3BU13
H3BUW1 P14618 PKM2-012
-TSL:1

TSL1: All splice junctions of the transcript are supported by at least one non-suspect mRNA.

The Transcript Support Level (TSL) is a method to highlight the well-supported and poorly-supported transcript models for users. The method relies on the primary data that can support full-length transcript structure: mRNA and EST alignments supplied by UCSC and Ensembl.

GENCODE basicThe GENCODE set is the gene set for human and mouse. GENCODE Basic is a subset of representative transcripts (splice variants).APPRIS CI1APPRIS candidate principal isoform (longest coding sequence) [01-09-2014]
Glossary entry for APPRIS
APPRIS website
PKM-004ENST000003351812318531 aa
 
Protein codingGenes and/or transcript that contains an open reading frame (ORF).
CCDS32284H3BN34 H3BT25 H3BTJ2
H3BU13 H3BUW1 P14618
PKM2-004 Q8WUW7 Q9UKK4
V9HWB8
NM_002654
NP_002645
TSL:1

TSL1: All splice junctions of the transcript are supported by at least one non-suspect mRNA.

The Transcript Support Level (TSL) is a method to highlight the well-supported and poorly-supported transcript models for users. The method relies on the primary data that can support full-length transcript structure: mRNA and EST alignments supplied by UCSC and Ensembl.

GENCODE basicThe GENCODE set is the gene set for human and mouse. GENCODE Basic is a subset of representative transcripts (splice variants).APPRIS CI1APPRIS candidate principal isoform (longest coding sequence) [01-09-2014]
Glossary entry for APPRIS
APPRIS website
PKM-202ENST000003890932279457 aa
 
Protein codingGenes and/or transcript that contains an open reading frame (ORF).
CCDS73752B4DNK4 H3BN34 P14618
PKM2-202 Q8WUW7 Q9UKK4
NM_001206797
NP_001193726
TSL:5

TSL5: No single transcript (mRNA or EST) supports this transcript model's structure.

The Transcript Support Level (TSL) is a method to highlight the well-supported and poorly-supported transcript models for users. The method relies on the primary data that can support full-length transcript structure: mRNA and EST alignments supplied by UCSC and Ensembl.

GENCODE basicThe GENCODE set is the gene set for human and mouse. GENCODE Basic is a subset of representative transcripts (splice variants).
PKM-006ENST000005651542004531 aa
 
Protein codingGenes and/or transcript that contains an open reading frame (ORF).
CCDS32285A0A024R5Z9 H3BN34 H3BT25
H3BTJ2 H3BTN5 H3BU13
H3BUW1 P14618 PKM2-006
-TSL:2

TSL2: The best supporting mRNA is flagged as suspect or the support is from multiple ESTs.

The Transcript Support Level (TSL) is a method to highlight the well-supported and poorly-supported transcript models for users. The method relies on the primary data that can support full-length transcript structure: mRNA and EST alignments supplied by UCSC and Ensembl.

GENCODE basicThe GENCODE set is the gene set for human and mouse. GENCODE Basic is a subset of representative transcripts (splice variants).APPRIS CI1APPRIS candidate principal isoform (longest coding sequence) [01-09-2014]
Glossary entry for APPRIS
APPRIS website
PKM-007ENST000005684591806531 aa
 
Protein codingGenes and/or transcript that contains an open reading frame (ORF).
CCDS32285A0A024R5Z9 H3BN34 H3BT25
H3BTJ2 H3BTN5 H3BU13
H3BUW1 P14618 PKM2-007
NM_001206799
NP_001193728
TSL:1

TSL1: All splice junctions of the transcript are supported by at least one non-suspect mRNA.

The Transcript Support Level (TSL) is a method to highlight the well-supported and poorly-supported transcript models for users. The method relies on the primary data that can support full-length transcript structure: mRNA and EST alignments supplied by UCSC and Ensembl.

GENCODE basicThe GENCODE set is the gene set for human and mouse. GENCODE Basic is a subset of representative transcripts (splice variants).APPRIS CI1APPRIS candidate principal isoform (longest coding sequence) [01-09-2014]
Glossary entry for APPRIS
APPRIS website
PKM-204ENST000005688831863366 aa
 
Protein codingGenes and/or transcript that contains an open reading frame (ORF).
-PKM2-204 -TSL:5

TSL5: No single transcript (mRNA or EST) supports this transcript model's structure.

The Transcript Support Level (TSL) is a method to highlight the well-supported and poorly-supported transcript models for users. The method relies on the primary data that can support full-length transcript structure: mRNA and EST alignments supplied by UCSC and Ensembl.

GENCODE basicThe GENCODE set is the gene set for human and mouse. GENCODE Basic is a subset of representative transcripts (splice variants).
PKM-008ENST000005616091568485 aa
 
Protein codingGenes and/or transcript that contains an open reading frame (ORF).
-H3BN34 H3BT25 H3BTJ2
H3BTN5 H3BU13 H3BUW1
PKM2-008
-CDS 3' incomplete3' truncation in transcript evidence prevents annotation of the end of the CDS.TSL:1

TSL1: All splice junctions of the transcript are supported by at least one non-suspect mRNA.

The Transcript Support Level (TSL) is a method to highlight the well-supported and poorly-supported transcript models for users. The method relies on the primary data that can support full-length transcript structure: mRNA and EST alignments supplied by UCSC and Ensembl.

PKM-017ENST00000562997582162 aa
 
Protein codingGenes and/or transcript that contains an open reading frame (ORF).
-H3BN34 H3BT25 H3BU13
H3BUW1 PKM2-017
-CDS 3' incomplete3' truncation in transcript evidence prevents annotation of the end of the CDS.TSL:4

TSL4:The best supporting EST for this transcript is flagged as suspect.

The Transcript Support Level (TSL) is a method to highlight the well-supported and poorly-supported transcript models for users. The method relies on the primary data that can support full-length transcript structure: mRNA and EST alignments supplied by UCSC and Ensembl.

PKM-019ENST0000056680956082 aa
 
Protein codingGenes and/or transcript that contains an open reading frame (ORF).
-H3BN34 H3BU13 PKM2-019
-CDS 3' incomplete3' truncation in transcript evidence prevents annotation of the end of the CDS.TSL:4

TSL4:The best supporting EST for this transcript is flagged as suspect.

The Transcript Support Level (TSL) is a method to highlight the well-supported and poorly-supported transcript models for users. The method relies on the primary data that can support full-length transcript structure: mRNA and EST alignments supplied by UCSC and Ensembl.

PKM-016ENST00000564178554168 aa
 
Protein codingGenes and/or transcript that contains an open reading frame (ORF).
-H3BN34 H3BT25 H3BTJ2
H3BU13 H3BUW1 PKM2-016
-CDS 3' incomplete3' truncation in transcript evidence prevents annotation of the end of the CDS.TSL:4

TSL4:The best supporting EST for this transcript is flagged as suspect.

The Transcript Support Level (TSL) is a method to highlight the well-supported and poorly-supported transcript models for users. The method relies on the primary data that can support full-length transcript structure: mRNA and EST alignments supplied by UCSC and Ensembl.

PKM-020ENST00000567087550151 aa
 
Protein codingGenes and/or transcript that contains an open reading frame (ORF).
-H3BN34 H3BT25 H3BU13
PKM2-020
-CDS 3' incomplete3' truncation in transcript evidence prevents annotation of the end of the CDS.TSL:4

TSL4:The best supporting EST for this transcript is flagged as suspect.

The Transcript Support Level (TSL) is a method to highlight the well-supported and poorly-supported transcript models for users. The method relies on the primary data that can support full-length transcript structure: mRNA and EST alignments supplied by UCSC and Ensembl.

PKM-018ENST0000056905045752 aa
 
Protein codingGenes and/or transcript that contains an open reading frame (ORF).
-H3BN34 PKM2-018 -CDS 3' incomplete3' truncation in transcript evidence prevents annotation of the end of the CDS.TSL:4

TSL4:The best supporting EST for this transcript is flagged as suspect.

The Transcript Support Level (TSL) is a method to highlight the well-supported and poorly-supported transcript models for users. The method relies on the primary data that can support full-length transcript structure: mRNA and EST alignments supplied by UCSC and Ensembl.

PKM-005ENST00000567118225469 aa
 
Nonsense mediated decayTranscript is thought to undergo nonsense mediated decay, a process which detects nonsense mutations and prevents the expression of truncated or erroneous proteins.
-H3BN34 H3BQZ3 PKM2-005
-TSL:2

TSL2: The best supporting mRNA is flagged as suspect or the support is from multiple ESTs.

The Transcript Support Level (TSL) is a method to highlight the well-supported and poorly-supported transcript models for users. The method relies on the primary data that can support full-length transcript structure: mRNA and EST alignments supplied by UCSC and Ensembl.

PKM-002ENST000005698571355281 aa
 
Nonsense mediated decayTranscript is thought to undergo nonsense mediated decay, a process which detects nonsense mutations and prevents the expression of truncated or erroneous proteins.
-H3BN34 H3BQ34 H3BT25
H3BTJ2 H3BU13 H3BUW1
PKM2-002
-TSL:5

TSL5: No single transcript (mRNA or EST) supports this transcript model's structure.

The Transcript Support Level (TSL) is a method to highlight the well-supported and poorly-supported transcript models for users. The method relies on the primary data that can support full-length transcript structure: mRNA and EST alignments supplied by UCSC and Ensembl.

PKM-009ENST000005644403016No protein
 
Retained intronAlternatively spliced transcript that is believed to contain intronic sequence relative to other coding transcripts in a given locus.
-PKM2-009 -TSL:1

TSL1: All splice junctions of the transcript are supported by at least one non-suspect mRNA.

The Transcript Support Level (TSL) is a method to highlight the well-supported and poorly-supported transcript models for users. The method relies on the primary data that can support full-length transcript structure: mRNA and EST alignments supplied by UCSC and Ensembl.

PKM-010ENST000005651432301No protein
 
Retained intronAlternatively spliced transcript that is believed to contain intronic sequence relative to other coding transcripts in a given locus.
-PKM2-010 -TSL:1

TSL1: All splice junctions of the transcript are supported by at least one non-suspect mRNA.

The Transcript Support Level (TSL) is a method to highlight the well-supported and poorly-supported transcript models for users. The method relies on the primary data that can support full-length transcript structure: mRNA and EST alignments supplied by UCSC and Ensembl.

PKM-014ENST00000563986825No protein
 
Retained intronAlternatively spliced transcript that is believed to contain intronic sequence relative to other coding transcripts in a given locus.
-PKM2-014 -TSL:2

TSL2: The best supporting mRNA is flagged as suspect or the support is from multiple ESTs.

The Transcript Support Level (TSL) is a method to highlight the well-supported and poorly-supported transcript models for users. The method relies on the primary data that can support full-length transcript structure: mRNA and EST alignments supplied by UCSC and Ensembl.

PKM-026ENST00000564276753No protein
 
Retained intronAlternatively spliced transcript that is believed to contain intronic sequence relative to other coding transcripts in a given locus.
-PKM2-026 -TSL:1

TSL1: All splice junctions of the transcript are supported by at least one non-suspect mRNA.

The Transcript Support Level (TSL) is a method to highlight the well-supported and poorly-supported transcript models for users. The method relies on the primary data that can support full-length transcript structure: mRNA and EST alignments supplied by UCSC and Ensembl.

PKM-022ENST00000563275699No protein
 
Retained intronAlternatively spliced transcript that is believed to contain intronic sequence relative to other coding transcripts in a given locus.
-PKM2-022 -TSL:1

TSL1: All splice junctions of the transcript are supported by at least one non-suspect mRNA.

The Transcript Support Level (TSL) is a method to highlight the well-supported and poorly-supported transcript models for users. The method relies on the primary data that can support full-length transcript structure: mRNA and EST alignments supplied by UCSC and Ensembl.

PKM-013ENST00000564993663No protein
 
Retained intronAlternatively spliced transcript that is believed to contain intronic sequence relative to other coding transcripts in a given locus.
-PKM2-013 -TSL:2

TSL2: The best supporting mRNA is flagged as suspect or the support is from multiple ESTs.

The Transcript Support Level (TSL) is a method to highlight the well-supported and poorly-supported transcript models for users. The method relies on the primary data that can support full-length transcript structure: mRNA and EST alignments supplied by UCSC and Ensembl.

PKM-015ENST00000570166626No protein
 
Retained intronAlternatively spliced transcript that is believed to contain intronic sequence relative to other coding transcripts in a given locus.
-PKM2-015 -TSL:2

TSL2: The best supporting mRNA is flagged as suspect or the support is from multiple ESTs.

The Transcript Support Level (TSL) is a method to highlight the well-supported and poorly-supported transcript models for users. The method relies on the primary data that can support full-length transcript structure: mRNA and EST alignments supplied by UCSC and Ensembl.

PKM-025ENST00000568743580No protein
 
Retained intronAlternatively spliced transcript that is believed to contain intronic sequence relative to other coding transcripts in a given locus.
-PKM2-025 -TSL:2

TSL2: The best supporting mRNA is flagged as suspect or the support is from multiple ESTs.

The Transcript Support Level (TSL) is a method to highlight the well-supported and poorly-supported transcript models for users. The method relies on the primary data that can support full-length transcript structure: mRNA and EST alignments supplied by UCSC and Ensembl.

PKM-024ENST00000562784529No protein
 
Retained intronAlternatively spliced transcript that is believed to contain intronic sequence relative to other coding transcripts in a given locus.
-PKM2-024 -TSL:2

TSL2: The best supporting mRNA is flagged as suspect or the support is from multiple ESTs.

The Transcript Support Level (TSL) is a method to highlight the well-supported and poorly-supported transcript models for users. The method relies on the primary data that can support full-length transcript structure: mRNA and EST alignments supplied by UCSC and Ensembl.

Statistics

Exons: 12 Coding exons: 10 Transcript length: 2,004 bps Translation length: 531 residues

CCDS

This transcript is a member of the Human CCDS set: CCDS32285

Uniprot

This transcript corresponds to the following Uniprot identifiers: P14618

Transcript Support Level

2

Ensembl version

ENST00000565154.3

Type

Novel protein coding

Prediction Method

Transcript where the Ensembl genebuild transcript and the Vega manual annotation have the same sequence, for every base pair. See article.

Alternative transcripts

This transcript corresponds to the following database identifiers:

Havana transcript:
GENCODE basic gene

This transcript is a member of the Gencode basic gene set.

Transcript-based displays