Description

programmed cell death 1 [Source:HGNC Symbol;Acc:HGNC:8760]

Synonyms

CD279, hSLE1, PD1, SLEB2

Location

Chromosome 2: 241,849,881-241,858,908 reverse strand.

View alleles of this gene on alternate assemblies

INSDC coordinates

chromosome:GRCh38:CM000664.2:241849881:241858908:1

About this gene

This gene has 3 transcripts (splice variants), 1 gene allele, 39 orthologues, is a member of 2 Ensembl protein families and is associated with 2 phenotypes.

NameTranscript IDbpProteinTranslation IDBiotypeCCDSUniProtRefSeqFlags
PDCD1-001ENST000003344092114288aaENSP00000335062
 
Protein codingGenes and/or transcript that contains an open reading frame (ORF).
CCDS33428Q15116 NM_005018
NP_005009
TSL:1

Transcript Support Level 1, when transcripts are supported by at least one non-suspect mRNA.

The Transcript Support Level (TSL) is a method to highlight the well-supported and poorly-supported transcript models for users. The method relies on the primary data that can support full-length transcript structure: mRNA and EST alignments supplied by UCSC and Ensembl.

GENCODE basicThe GENCODE set is the gene set for human and mouse. GENCODE Basic is a subset of representative transcripts (splice variants).APPRIS P1

PRINCIPAL1 - APPRIS candidate principal isoform.

APPRIS is a system to annotate alternatively spliced transcripts based on a range of computational methods.

PDCD1-003ENST00000343705366123aaENSP00000340808
 
Protein codingGenes and/or transcript that contains an open reading frame (ORF).
-H0Y2W6 -CDS 5' and 3' incomplete5' and 3' truncations in transcript evidence prevent annotation of the start and the end of the CDS.TSL:1

Transcript Support Level 1, when transcripts are supported by at least one non-suspect mRNA.

The Transcript Support Level (TSL) is a method to highlight the well-supported and poorly-supported transcript models for users. The method relies on the primary data that can support full-length transcript structure: mRNA and EST alignments supplied by UCSC and Ensembl.

PDCD1-002ENST00000418831101966aaENSP00000390296
 
Nonsense mediated decayTranscript is thought to undergo nonsense mediated decay, a process which detects nonsense mutations and prevents the expression of truncated or erroneous proteins.
-E7ER21 -TSL:1

Transcript Support Level 1, when transcripts are supported by at least one non-suspect mRNA.

The Transcript Support Level (TSL) is a method to highlight the well-supported and poorly-supported transcript models for users. The method relies on the primary data that can support full-length transcript structure: mRNA and EST alignments supplied by UCSC and Ensembl.

Gene-based displays