Description

proprotein convertase subtilisin/kexin type 5 [Source:HGNC Symbol;Acc:HGNC:8747]

Synonyms

PC5, PC6, SPC6

Location
INSDC coordinates

chromosome:GRCh38:CM000671.2:75890644:76362339:1

About this gene

This gene has 5 transcripts (splice variants), 68 orthologues, 6 paralogues, is a member of 1 Ensembl protein family and is associated with 195 phenotypes.

NameTranscript IDbpProteinTranslation IDBiotypeCCDSUniProtRefSeqFlags
PCSK5-201ENST0000054512895381860aaENSP00000446280
 
Protein codingGenes and/or transcript that contains an open reading frame (ORF).
CCDS55320Q92824 NM_001190482
NP_001177411
TSL:5

TSL5: No single transcript (mRNA or EST) supports this transcript model's structure.

The Transcript Support Level (TSL) is a method to highlight the well-supported and poorly-supported transcript models for users. The method relies on the primary data that can support full-length transcript structure: mRNA and EST alignments supplied by UCSC and Ensembl.

GENCODE basicThe GENCODE set is the gene set for human and mouse. GENCODE Basic is a subset of representative transcripts (splice variants).APPRIS ALT2APPRIS candidate principal isoform that appears to be conserved in fewer than three tested non-primate species
Glossary entry for APPRIS
APPRIS website
PCSK5-001ENST000003767525756913aaENSP00000365943
 
Protein codingGenes and/or transcript that contains an open reading frame (ORF).
CCDS6652Q92824 NM_006200
NP_006191
TSL:1

TSL1: All splice junctions of the transcript are supported by at least one non-suspect mRNA.

The Transcript Support Level (TSL) is a method to highlight the well-supported and poorly-supported transcript models for users. The method relies on the primary data that can support full-length transcript structure: mRNA and EST alignments supplied by UCSC and Ensembl.

GENCODE basicThe GENCODE set is the gene set for human and mouse. GENCODE Basic is a subset of representative transcripts (splice variants).APPRIS PI3APPRIS candidate principal isoform (earliest CCDS)
Glossary entry for APPRIS
APPRIS website
PCSK5-002ENST0000042485447311560aaENSP00000411654
 
Protein codingGenes and/or transcript that contains an open reading frame (ORF).
-Q5JSG7 -CDS 5' incomplete5' truncation in transcript evidence prevents annotation of the start of the CDS.TSL:5

TSL5: No single transcript (mRNA or EST) supports this transcript model's structure.

The Transcript Support Level (TSL) is a method to highlight the well-supported and poorly-supported transcript models for users. The method relies on the primary data that can support full-length transcript structure: mRNA and EST alignments supplied by UCSC and Ensembl.

PCSK5-003ENST000003767672845690aaENSP00000365958
 
Protein codingGenes and/or transcript that contains an open reading frame (ORF).
-B1AMG5 -TSL:2

TSL2: The best supporting mRNA is flagged as suspect or the support is from multiple ESTs.

The Transcript Support Level (TSL) is a method to highlight the well-supported and poorly-supported transcript models for users. The method relies on the primary data that can support full-length transcript structure: mRNA and EST alignments supplied by UCSC and Ensembl.

GENCODE basicThe GENCODE set is the gene set for human and mouse. GENCODE Basic is a subset of representative transcripts (splice variants).
PCSK5-004ENST00000455778503101aaENSP00000407239
 
Protein codingGenes and/or transcript that contains an open reading frame (ORF).
-B1AMG8 -CDS 5' incomplete5' truncation in transcript evidence prevents annotation of the start of the CDS.TSL:3

TSL3:The only support for this transcript is from a single EST.

The Transcript Support Level (TSL) is a method to highlight the well-supported and poorly-supported transcript models for users. The method relies on the primary data that can support full-length transcript structure: mRNA and EST alignments supplied by UCSC and Ensembl.

Gene-based displays