Protein Families are groups of proteins with high sequence similarity. They result from classifying all Ensembl proteins and all the metazoan proteins from UniProtKB (SwissProt and TrEMBL) against the TreeFam HMM library. Clusters are then aligned with Mafft.
The consensus annotation column shows the family name, which is assigned if over 40% of the members have the same name. For more on this naming, see the article.
To view protein alignments in the JalView alignment editor, click on the JalView links at the right of the page.