Top 40 InterPro Domains in the Ensembl Database

No.

Interpro name	Number of genes	Number of Ensembl hits	No.	Interpro name	Number of genes	Number of Ensembl hits
1	IPR000719 Protein kinase, core	772	16475	21	IPR001092 Basic helix-loop-helix dimerisation region bHLH	100	653
2	IPR000276 Rhodopsin-like GPCR superfamily	525	13500	22	IPR001128 Cytochrome P450	98	4670
3	IPR000694 Proline-rich region	510	10133	23	IPR000152 Aspartic acid and asparagine hydroxylation site	91	15132
4	IPR000533 Tropomyosin	243	3080	24	IPR002048 Calcium-binding EF-hand	90	1027
5	IPR003596 Immunoglobulin V-set, subgroup	212	6027	25	IPR000048 IQ calmodulin-binding region	88	2449
6	IPR000504 RNA recognition motif, RNP-1	210	2485	26	IPR007086 Zinc finger, C2H2-subtype	84	2160
7	IPR000047 Helix-turn-helix motif, lambda-like repressor	206	3278	27	IPR002126 Cadherin	82	4515
8	IPR007111 NACHT nucleoside triphosphatase	203	313	28	IPR003598 Immunoglobulin subtype 2	81	1782
9	IPR001806 Ras GTPase	180	2698	29	IPR002198 Short-chain dehydrogenase/reductase SDR	80	1269
10	IPR000315 Zinc finger, B-box	179	7261	30	IPR000108 Neutrophil cytosol factor 2	76	4308
11	IPR000210 BTB/POZ-like	175	4467	31	IPR001356 Homeobox	76	924
12	IPR001304 C-type lectin	172	2654	32	IPR007087 Zinc finger, C2H2-type	74	1193
13	IPR001680 WD40 repeat	162	4145	33	IPR001452 Src homology-3	71	1740
14	IPR001841 Zinc finger, RING-type	149	1285	34	IPR001440 Tetratricopeptide TPR_1	68	1753
15	IPR000008 C2 calcium-dependent membrane targeting	136	3611	35	IPR001878 Zinc finger, CCHC-type	67	354
16	IPR001254 Peptidase S1 and S6, chymotrypsin/Hap	132	1937	36	IPR001478 PDZ/DHR/GLGF	65	824
17	IPR001781 LIM, zinc-binding	123	6411	37	IPR000372 Leucine-rich repeat, cysteine-rich flanking region, N-terminal	65	1593
18	IPR014891 DWNN domain	120	128	38	IPR000198 RhoGAP	64	980
19	IPR002110 Ankyrin	103	2555	39	IPR001993 Mitochondrial substrate carrier	62	1301
20	IPR001611 Leucine-rich repeat	102	1854	40	IPR000169 Peptidase, cysteine peptidase active site	61	1281

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